Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling

被引:62
作者
Hussain, Md Sadique [1 ]
Afzal, Obaid [2 ]
Gupta, Gaurav [3 ,4 ,13 ]
Altamimi, Abdulmalik Saleh Alfawaz [2 ]
Almalki, Waleed Hassan [5 ]
Alzarea, Sami I. [6 ]
Kazmi, Imran [7 ]
Fuloria, Neeraj Kumar [8 ]
Sekar, Mahendran [9 ]
Meenakshi, Dhanalekshmi Unnikrishnan [10 ]
Thangavelu, Lakshmi [11 ]
Sharma, Ajay [12 ]
机构
[1] Jaipur Natl Univ, Sch Pharmaceut Sci, Jaipur 302017, Rajasthan, India
[2] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut Chem, Alkharj 11942, Saudi Arabia
[3] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur, India
[4] Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun, India
[5] Umm Al Qura Univ, Coll Pharm, Dept Pharmacol, Mecca, Saudi Arabia
[6] Jouf Univ, Coll Pharm, Dept Pharmacol, Sakaka, Al Jouf, Saudi Arabia
[7] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia
[8] AIMST Univ, Fac Pharm, Bedong 08100, Kedah, Malaysia
[9] Monash Univ Malaysia, Sch Pharm, Subang Jaya 47500, Selangor, Malaysia
[10] Natl Univ Sci & Technol, Coll Pharm, Muscat 130, Oman
[11] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll, Ctr Global Hlth Res, Chennai, Tamil Nadu, India
[12] Delhi Pharmaceut Sci & Res Univ, Pushp Vihar Sect 3,MB Rd, New Delhi 110017, India
[13] Graph Era Hill Univ, Sch Pharm, Dehra Dun 248007, India
关键词
Lung cancer; MAPK; LncRNAs; Metastasis; Molecular mechanisms; EPITHELIAL-MESENCHYMAL TRANSITION; REGULATES CELL-PROLIFERATION; POOR-PROGNOSIS; C-MYC; MALIGNANT-TRANSFORMATION; COLORECTAL-CANCER; PROMOTES PROLIFERATION; MALAT1; PROMOTES; CIGARETTE-SMOKE; DOWN-REGULATION;
D O I
10.1016/j.prp.2023.154738
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Lung cancer (LC) continues to pose a significant global medical burden, necessitating a comprehensive under-standing of its molecular foundations to establish effective treatment strategies. The mitogen-activated protein kinase (MAPK) signaling system has been scientifically associated with LC growth; however, the intricate reg-ulatory mechanisms governing this system remain unknown. Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of diverse cellular activities, including cancer growth. LncRNAs have been implicated in LC, which can function as oncogenes or tumor suppressors, and their dysregulation has been linked to cancer cell death, metastasis, spread, and proliferation. Due to their involvement in critical pathophysiological processes, lncRNAs are gaining attention as potential candidates for anti-cancer treatments. This article aims to elucidate the regulatory role of lncRNAs in MAPK signaling in LC. We provide a comprehensive review of the key com-ponents of the MAPK pathway and their relevance in LC, focusing on aberrant signaling processes associated with disease progression. By examining recent research and experimental findings, this article examines the molecular mechanisms through which lncRNAs influence MAPK signaling in lung cancer, ultimately contributing to tumor development.
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页数:11
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