Comprehensive analysis of the role of SFXN family in breast cancer

被引:5
作者
Yuan, Ding [1 ]
Liu, Jialiang [1 ]
Sang, Wenbo [1 ]
Li, Qing [1 ]
机构
[1] Shouguang City Peoples Hosp, Dept Gen Surg, Shouguang 262700, Peoples R China
关键词
sideroflexin; breast cancer; biomarkers; prognosis; EXPRESSION; PROTEIN; DOXORUBICIN; SURVIVAL;
D O I
10.1515/med-2023-0685
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The sideroflexin (SFXN) family is a group of mitochondrial membrane proteins. Although the function of the SFXN family in mitochondria has been widely recognized, the expression levels, role, and prognostic value of this family in breast cancer (BC) have not been clearly articulated and systematically analysed. In our research, SFXN1 and SFXN2 were significantly upregulated in BC versus normal samples based on Gene Expression Profiling Interactive Analysis 2 and the Human Protein Atlas databases. We found that high SFXN1 expression was significantly related to poor prognosis in BC patients and that high SFXN2 expression was significantly associated with good prognosis in BC patients. Gene Ontology analysis of the SFXN family was performed based on the STRING database to explore the potential functions of this family, including biological processes, cellular components, and molecular functions. Based on the MethSurv database, we found that two SFXN1 CpG sites (5 '-UTR-S_Shelf-cg06573254 and TSS200-Island-cg17647431), two SFXN2 CpG sites (3 '-UTR-Open_Sea-cg04774043 and Body-Open_Sea-cg18994254), one SFXN3 CpG site (Body-S_Shelf-cg17858697), and nine SFXN5 CpG sites (1stExon;5 '-UTR-Island-cg03856450, Body-Open_Sea-cg04016113, Body-Open_Sea-cg04197631, Body-Open_Sea-cg07558704, Body-Open_Sea-cg08383863, Body-Open_Sea-cg10040131, Body-Open_Sea-cg10588340, Body-Open_Sea-cg17046766, and Body-Open_Sea-cg22830638) were significantly related to the prognosis of BC patients. According to the ENCORI database, four negative regulatory miRNAs for SFXN1 (hsa-miR-22-3p, hsa-miR-140-5p, hsa-miR-532-5p, and hsa-miR-582-3p) and four negative regulatory miRNAs for SFXN2 (hsa-miR-9-5p, hsa-miR-34a-5p, hsa-miR-532-5p, and hsa-miR-885-5p) were related to poor prognosis for BC patients. This study suggests that SFXN1 and SFXN2 are valuable biomarkers and treatment targets for patients with BC.
引用
收藏
页数:14
相关论文
共 43 条
[1]   The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism [J].
Acoba, Michelle Grace ;
Alpergin, Ebru S. Selen ;
Renuse, Santosh ;
Fernandez-del-Rio, Lucia ;
Lu, Ya-Wen ;
Khalimonchuk, Oleh ;
Clarke, Catherine F. ;
Pandey, Akhilesh ;
Wolfgang, Michael J. ;
Claypool, Steven M. .
CELL REPORTS, 2021, 34 (11)
[2]   Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology [J].
Amorim, Ines S. ;
Graham, Laura C. ;
Carter, Roderick N. ;
Morton, Nicholas M. ;
Hammachi, Fella ;
Kunath, Tilo ;
Pennetta, Giuseppa ;
Carpanini, Sarah M. ;
Manson, Jean C. ;
Lamont, Douglas J. ;
Wishart, Thomas M. ;
Gillingwater, Thomas H. .
JOURNAL OF CELL SCIENCE, 2017, 130 (02) :325-331
[3]   The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data [J].
Cerami, Ethan ;
Gao, Jianjiong ;
Dogrusoz, Ugur ;
Gross, Benjamin E. ;
Sumer, Selcuk Onur ;
Aksoy, Buelent Arman ;
Jacobsen, Anders ;
Byrne, Caitlin J. ;
Heuer, Michael L. ;
Larsson, Erik ;
Antipin, Yevgeniy ;
Reva, Boris ;
Goldberg, Arthur P. ;
Sander, Chris ;
Schultz, Nikolaus .
CANCER DISCOVERY, 2012, 2 (05) :401-404
[4]   Integrin α6β4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells [J].
Chen, M ;
O'Connor, KL .
ONCOGENE, 2005, 24 (32) :5125-5130
[5]   Elevated SFXN2 limits mitochondrial autophagy and increases iron-mediated energy production to promote multiple myeloma cell proliferation [J].
Chen, Ying ;
Qian, Jinjun ;
Ding, Pinggang ;
Wang, Wang ;
Li, Xinying ;
Tang, Xiaozhu ;
Tang, Chao ;
Yang, Ye ;
Gu, Chunyan .
CELL DEATH & DISEASE, 2022, 13 (09)
[6]   Prospective role and immunotherapeutic targets of sideroflexin protein family in lung adenocarcinoma: evidence from bioinformatics validation [J].
Dang, Huy Hoang ;
Ta, Hoang Dang Khoa ;
Nguyen, Truc T. T. ;
Anuraga, Gangga ;
Wang, Chih-Yang ;
Lee, Kuen-Haur ;
Nguyen Quoc Khanh Le .
FUNCTIONAL & INTEGRATIVE GENOMICS, 2022, 22 (05) :1057-1072
[7]   Prognosis of Women With Metastatic Breast Cancer by HER2 Status and Trastuzumab Treatment: An Institutional-Based Review [J].
Dawood, Shaheenah ;
Broglio, Kristine ;
Buzdar, Aman U. ;
Hortobagyi, Gabriel N. ;
Giordano, Sharon H. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (01) :92-98
[8]   Identification of Prognostic Organic Cation and Anion Transporters in Different Cancer Entities by In Silico Analysis [J].
Edemir, Bayram .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (12) :1-14
[9]  
Ellisen LW, 1998, ANNU REV MED, V49, P425
[10]   SERAC1 is a component of the mitochondrial serine transporter complex required for the maintenance of mitochondrial DNA [J].
Fang, Hezhi ;
Xie, Anran ;
Du, Miaomiao ;
Li, Xueyun ;
Yang, Kaiqiang ;
Fu, Yinxu ;
Yuan, Xiangshu ;
Fan, Runxiao ;
Yu, Weidong ;
Zhou, Zhuohua ;
Sang, Tiantian ;
Nie, Ke ;
Li, Jin ;
Zhao, Qiongya ;
Chen, Zhehui ;
Yang, Yanling ;
Hong, Chaoyang ;
Lyu, Jianxin .
SCIENCE TRANSLATIONAL MEDICINE, 2022, 14 (634)