Gabapentin-Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report

被引:1
作者
Orfao, Ana [1 ]
Madeira, Daniela [1 ]
Duarte, Daniel Maia [2 ]
Pereira, Filipa Galante [3 ]
Matos, Clara [1 ]
机构
[1] Hosp Prof Doutor Fernando Fonseca, Internal Med, Amadora, Portugal
[2] Hosp Prof Doutor Fernando Fonseca, Gen Med, Amadora, Portugal
[3] Hosp Prof Doutor Fernando Fonseca, Anat Pathol, Amadora, Portugal
关键词
skin biopsy; hypersensitivityvasculitis; small vessel vasculitis; leukocytoclastic vasculitis; gabapentin; CONSENSUS CONFERENCE NOMENCLATURE; PROBABILITY;
D O I
10.7759/cureus.44616
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Leukocytoclastic vasculitis (LCV) is a type of small vessel vasculitis, characterized by a perivascular neutrophilic inflammatory infiltrate with fibrinoid necrosis and fragmentation of nuclei ("leukocytoclasia"). Although up to half of the cases of LCV are idiopathic, infections and drugs are the most common secondary triggers for this condition. We present the case of an 88-year-old woman who developed an erythematous maculopapular rash on both thighs three days after starting gabapentin for neuropathic leg pain, without other associated symptoms. Skin biopsy was compatible with cutaneous vasculitis with a leukocytoclastic pattern. The skin lesions resolved within about 10 days after discontinuing gabapentin, supporting the diagnosis. To our knowledge, there are only four published cases of LCV secondary to gabapentin. This case highlights the importance of being alert for diagnosing drug-related cutaneous manifestations, even if the drug is used in our daily practice and vasculitis is not a common side effect, since discontinuing the suspected agent is crucial to resolve skin lesions and to avoid more serious complications.
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页数:7
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