Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA)

被引：15

作者：

Ali, Jaber Haj ^{[1
,2
]}

Walter, Michael ^{[2
]}

机构：

[1] Charite Univ Med Berlin, Inst Lab Med Clin Chem & Pathobiochemi, Augustenburger Pl 1, D-13353 Berlin, Germany

[2] Univ Med Rostock, Inst Clin Chem & Lab Med, Ernst Heydemann Str 6, D-18057 Rostock, Germany

来源：

CANCER CELL INTERNATIONAL | 2023年 / 23卷 / 01期

关键词：

Telomerase; Cancer therapy; Cancer; TICCA; Telomere; Transient immediate complete and combinatory attack; REVERSE-TRANSCRIPTASE HTERT; CATALYTIC SUBUNIT HTERT; TERT PROMOTER MUTATIONS; HUMAN TUMOR-CELLS; G-QUADRUPLEX DNA; PEPTIDE VACCINATION; PLATINUM(II) COMPLEXES; GENE-EXPRESSION; DOWN-REGULATION; RNA GENE;

D O I：

10.1186/s12935-023-03041-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Telomerase can overcome replicative senescence by elongation of telomeres but is also a specific element in most cancer cells. It is expressed more vastly than any other tumor marker. Telomerase as a tumor target inducing replicative immortality can be overcome by only one other mechanism: alternative lengthening of telomeres (ALT). This limits the probability to develop resistance to treatments. Moreover, telomerase inhibition offers some degree of specificity with a low risk of toxicity in normal cells. Nevertheless, only one telomerase antagonist reached late preclinical studies. The underlying causes, the pitfalls of telomerase-based therapies, and future chances based on recent technical advancements are summarized in this review. Based on new findings and approaches, we propose a concept how long-term survival in telomerase-based cancer therapies can be significantly improved: the TICCA (Transient Immediate Complete and Combinatory Attack) strategy.

引用

页数：24

共 281 条

[1] The Small Molecule BIBR1532 Exerts Potential Anti-cancer Activities in Preclinical Models of Feline Oral Squamous Cell Carcinoma Through Inhibition of Telomerase Activity and Down-Regulation of TERT [J].