Role of ClpP in the anti-cancer effects of imipridone ONC201 and ONC206

被引:0
作者
Lee, Andrew
Maranto, Cristina
Foster, Scott
Morrow, Sara
Allen, Joshua E.
Lanier, Randall
Sethna, Phiroze
Prabhu, Varun V.
机构
关键词
D O I
10.1158/1538-7445.AM2023-4914
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4914
引用
收藏
页数:2
相关论文
共 50 条
[11]   Synergistic combination therapy with ONC201 or ONC206, and enzalutamide or darolutamide in preclinical studies of castration-resistant prostate cancer [J].
Wu, Laura Jinxuan ;
Pinho-Schwermann, Maximilian ;
Zhou, Lanlan ;
Zhang, Leiqing ;
Huntington, Kelsey E. ;
Malpass, Ryan ;
Seyhan, Attila A. ;
Carneiro, Benedito A. ;
El-Deiry, Wafik S. .
AMERICAN JOURNAL OF CANCER RESEARCH, 2024, 14 (12) :6012-6036
[12]   ONC201 and imipridones: Anti-cancer compounds with clinical efficacy [J].
Prabhu, Varun Vijay ;
Morrow, Sara ;
Kawakibi, Abed Rahman ;
Zhou, Lanlan ;
Ralff, Marie ;
Ray, Jocelyn ;
Jhaveri, Aakash ;
Ferrarini, Isacco ;
Lee, Young ;
Parker, Cassandra ;
Zhang, Yiqun ;
Borsuk, Robyn ;
Chang, Wen-I ;
Honeymanb, Joshua N. ;
Tavora, Fabio ;
Carneiro, Benedito ;
Raufi, Alexander ;
Huntington, Kelsey ;
Carlsen, Lindsey ;
Louie, Anna ;
Safran, Howard ;
Seyhan, Attila A. ;
Tarapore, Rohinton S. ;
Schalop, Lee ;
Stogniew, Martin ;
Allen, Joshua E. ;
Oster, Wolfgang ;
El-Deiry, Wafik S. .
NEOPLASIA, 2020, 22 (12) :725-744
[13]   ONC201 AND ONC206 TARGET TUMOR CELL METABOLISM IN PEDIATRIC DIFFUSE MIDLINE GLIOMA PRECLINICAL MODELS [J].
Przystal, Justyna M. ;
Cosentino, Chiara Cianciolo ;
Yadavilli, Sridevi ;
Zhang, Jie ;
Laternser, Sandra ;
Bonner, Erin R. ;
Biery, Matt ;
Vitanza, Nicholas A. ;
Koschmann, Carl ;
Cain, Jason ;
Waszak, Sebastian M. ;
Mueller, Sabine ;
Nazarian, Javad .
NEURO-ONCOLOGY, 2021, 23 :23-24
[14]   BIOMARKER EVALUATION FOR IMIPRIDONE ONC206 REVEALS CLPP, ATF4, MYC, EGFR AND HIF1 AS KEY PREDICTORS OF ANTI-CANCER EFFICACY [J].
Morrow, Sara ;
Garnett, Mathew ;
McDermott, Ultan ;
Benes, Cyril ;
Allen, Joshua ;
Prabhu, Varun .
NEURO-ONCOLOGY, 2020, 22 :14-15
[15]   Potent anti-cancer activity of the imipridone ONC206: A selective dopamine D2-like receptor antagonist [J].
Prabhu, Varun Vijay ;
Madhukar, Neel ;
Wagner, Jessica ;
Tarapore, Rohinton ;
Garnett, Mathew ;
McDermott, Ultan ;
Benes, Cyril ;
Charter, Neil ;
Deacon, Sean ;
VanEngelenburg, Alexander ;
Elemento, Olivier ;
El-Deiry, Wafik ;
Stogniew, Martin ;
Oster, Wolfgang ;
Allen, Joshua .
CANCER RESEARCH, 2017, 77
[16]   Imipridone ONC201: combination therapy in hematologic malignancies [J].
Chari, Ajai ;
Barlogie, Bart .
CELL CYCLE, 2018, 17 (16) :1947-1948
[17]   Preclinical evaluation of the imipridone family of small molecules, including analogues of clinical-stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212 [J].
Wagner, Jessica ;
Kline, C. Leah ;
Olson, Gary ;
Nallaganchu, Bhaskara ;
Pottorf, Richard ;
Prabhu, Varun ;
Stogniew, Martin ;
Allen, Joshua ;
El-Deiry, Wafik .
CANCER RESEARCH, 2017, 77
[18]   Dopamine pre-treatment impairs the anti-cancer effect of integrated stress response- and TRAIL pathway-inducing ONC201, ONC206 and ONC212 imipridones in pancreatic, colorectal cancer but not DMG cells [J].
Zhang, Yiqun ;
Tapinos, Nikos ;
Lulla, Rishi ;
El-Deiry, Wafik S. .
AMERICAN JOURNAL OF CANCER RESEARCH, 2024, 14 (05)
[19]   Preclinical efficacy of new investigational drug ONC201 and analogs ONC212 and ONC206 against patient-derived pancreatic cancer cell lines. [J].
Lev, Avital ;
Wagner, Jessica ;
Lulla, Amriti R. ;
Dicker, David T. ;
El-Deiry, Wafik S. .
JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
[20]   Impact of hypoxia on the integrated stress response activated by imipridones ONC201 and ONC206 in pediatric diffuse midline glioma cells [J].
Roady, Tyler J. ;
Stubbs, Nolan ;
Chen, Josephine ;
Xia, Yutong ;
Uruchurtu, Ashley Sanchez Sevilla ;
Tian, Xiaobing ;
Zhou, Lanlan ;
El-Deiry, Wafik S. .
CANCER RESEARCH, 2024, 84 (06)