Dietary and metabolic effects on the oral status of patients with phenylketonuria: a nation-based cross-sectional study

被引：4

作者：

Bingoel, Anne Carolin ^{[1
,2
,3
]}

Bingoel, Memduh ^{[1
,2
,3
]}

Pandis, Nikolaos ^{[4
]}

Stolz, Simone ^{[5
]}

Beblo, Skadi ^{[6
]}

Jost-Brinkmann, Paul-Georg ^{[1
,2
,3
]}

Moench, Eberhard ^{[7
,8
,9
,10
]}

Bartzela, Theodosia ^{[1
,2
,3
,11
]}

机构：

[1] Charite Univ Med Berlin, Dept Orthodont & Dentofacial Orthoped, Assmannshauser Str 4-6, D-14197 Berlin, Germany

[2] Free Univ Berlin, Assmannshauser Str 4-6, D-14197 Berlin, Germany

[3] Humboldt Univ, Inst Oral Hlth Sci, Assmannshauser Str 4-6, D-14197 Berlin, Germany

[4] Univ Bern, Med Fac, Dent Sch, Dept Orthodont & Dentofacial Orthoped, Freiburgstr 7, CH-3010 Bern, Switzerland

[5] Carl Thiem Klinikum Cottbus, Dept Pediat & Adolescent Med, Thiemstr 111, D-03048 Cottbus, Germany

[6] Univ Leipzig, Hosp Children & Adolescents, Ctr Pediat Res Leipzig, Dept Women & Child Hlth, Liebigstr 20a,Haus 6, D-04103 Leipzig, Germany

[7] Charite Univ Med Berlin, Interdisciplinary Metab Ctr, Augustenburger Pl 1, D-13353 Berlin, Germany

[8] Free Univ Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany

[9] Humboldt Univ, Augustenburger Pl 1, D-13353 Berlin, Germany

[10] Campus Virchow Klinikum, Augustenburger Pl 1, D-13353 Berlin, Germany

[11] Tech Univ Dresden, Dept Orthodont, Fetscherstr 74, D-01307 Dresden, Germany

来源：

CLINICAL ORAL INVESTIGATIONS | 2023年 / 27卷 / 05期

关键词：

Phenylketonuria; Oral status; Caries; Enamel defects; Oral health; DENTAL-CARIES; NUTRITION MANAGEMENT; CHILDREN; INDEX; HYPOMINERALIZATION; FLUORIDE; DISEASE;

D O I：

10.1007/s00784-022-04827-w

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

ObjectivesThe aim of this study was to compare the prevalence of oral diseases (caries, periodontal disease, enamel defects) between patients with phenylketonuria (PKU), their siblings, and a matched control group.Materials and methodsA total of 109 patients with PKU, 14 siblings of PKU patients, and 100 healthy individuals aged 6 to 68 years were recruited. All participants completed a questionnaire based on their health status. The patients' decayed/missing/filled teeth index (dmft/DMFT), gingival bleeding index (GBI), plaque control record (PCR), periodontal screening and recording index (PSR), and developmental enamel defects index (DDE) were recorded. Descriptive statistics and regression modeling were used to examine potential associations between the exposure and the outcomes of interest.ResultsPatients with PKU had 1.6 times more caries (95% confidence interval (CI) 1.22 to 2.20; p = 0.001), seven times more enamel defects (95% CI 3.94 to 14.21; p < 0.001), and four times higher PSR values (95% CI 2.26 to 7.15; p < 0.001) than the control group. The siblings had significantly fewer enamel defects but no significant differences in caries and periodontal parameters compared to the PKU patients.ConclusionsThe results showed a higher risk for the development of caries, periodontitis, and enamel defects in PKU patients.

引用

页码：1981 / 1991

页数：11

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