The role of sialidase Neu1 in respiratory diseases

被引：3
|
作者：
Mei, Shiran [1 ]
Li, Dingding [1 ]
Wang, Aoyi [1 ]
Zhu, Guoxue [1 ]
Zhou, Bingwen [1 ]
Li, Nian [1 ]
Qin, Yi [1 ]
Zhang, Yanliang [1 ,2 ]
Jiang, Shujun [1 ,2 ]
机构：
[1] Nanjing Univ Chinese Med, Nanjing Hosp Chinese Med, Nanjing, Peoples R China
[2] Nanjing Res Ctr Infect Dis Integrated Tradit Chine, Nanjing, Jiangsu, Peoples R China
来源：
RESPIRATORY RESEARCH | 2024年 / 25卷 / 01期
关键词：
IDIOPATHIC PULMONARY-FIBROSIS; SELECTIVE INHIBITORS; HUMAN NEURAMINIDASE; LYSOSOMAL SIALIDASE; T-LYMPHOCYTES; LUNG-CANCER; EXPRESSION; RECEPTOR; CD44; DIFFERENTIATION;
D O I：
10.1186/s12931-024-02763-9
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Neu1 is a sialidase enzyme that plays a crucial role in the regulation of glycosylation in a variety of cellular processes, including cellular signaling and inflammation. In recent years, numerous evidence has suggested that human NEU1 is also involved in the pathogenesis of various respiratory diseases, including lung infection, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis. This review paper aims to provide an overview of the current research on human NEU1 and respiratory diseases.
引用
收藏
页数：8
相关论文
共 50 条
  • [21] Neu1 Sialidase Regulates Nerve Growth Factor-Induced Trka Receptor Activation
    Jayanth, Preethi
    Amith, Schammim R.
    Szewczuk, Myron R.
    GLYCOBIOLOGY, 2009, 19 (11) : 1363 - 1363
  • [22] Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin β4
    T Uemura
    K Shiozaki
    K Yamaguchi
    S Miyazaki
    S Satomi
    K Kato
    H Sakuraba
    T Miyagi
    Oncogene, 2009, 28 : 1218 - 1229
  • [23] Desialylation of ATG5 by sialidase (NEU1) promotes macrophages autophagy and exacerbates inflammation under hypoxia
    Zeng, Shengmei
    Wen, Yilin
    Yu, Chao
    CELLULAR SIGNALLING, 2023, 112
  • [24] Pathogenic Cascade Downstream of Altered Processing of Sialic Acids on Glycoconjugates Due to Deficiency of the Lysosomal Sialidase NEU1
    d'Azzo, Alessandra
    GLYCOBIOLOGY, 2015, 25 (11) : 1239 - 1240
  • [25] Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis
    Luzina, Irina G.
    Lockatell, Virginia
    Hyun, Sang W.
    Kopach, Pavel
    Kang, Phillip H.
    Noor, Zahid
    Liu, Anguo
    Lillehoj, Erik P.
    Lee, Chunsik
    Miranda-Ribera, Alba
    Todd, Nevins W.
    Goldblum, Simeon E.
    Atamas, Sergei P.
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 310 (10) : L940 - L954
  • [26] Contribution of sialidase NEU1 to suppression of metastasis of human colon cancer cells through desialylation of integrin β4
    Uemura, T.
    Shiozaki, K.
    Yamaguchi, K.
    Miyazaki, S.
    Satomi, S.
    Kato, K.
    Sakuraba, H.
    Miyagi, T.
    ONCOGENE, 2009, 28 (09) : 1218 - 1229
  • [27] Dependence of pathogen molecule-induced Toll-like receptor activation and cell function on Neu1 sialidase
    Schammim Ray Amith
    Preethi Jayanth
    Susan Franchuk
    Sarah Siddiqui
    Volkan Seyrantepe
    Katrina Gee
    Sameh Basta
    Rudi Beyaert
    Alexey V. Pshezhetsky
    Myron R. Szewczuk
    Glycoconjugate Journal, 2009, 26 : 1197 - 1212
  • [28] Homology modeling of human sialidase enzymes NEU1, NEU3 and NEU4 based on the crystal structure of NEU2: Hints for the design of selective NEU3 inhibitors
    Magesh, Sadagopan
    Suzuki, Tohru
    Miyagi, Taeko
    Ishida, Hideharu
    Kiso, Makoto
    JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2006, 25 (02): : 196 - 207
  • [29] Dependence of pathogen molecule-induced Toll-like receptor activation and cell function on Neu1 sialidase
    Amith, Schammim Ray
    Jayanth, Preethi
    Franchuk, Susan
    Siddiqui, Sarah
    Seyrantepe, Volkan
    Gee, Katrina
    Basta, Sameh
    Beyaert, Rudi
    Pshezhetsky, Alexey V.
    Szewczuk, Myron R.
    GLYCOCONJUGATE JOURNAL, 2009, 26 (09) : 1197 - 1212
  • [30] Lysosomal localization of Japanese medaka (Oryzias latipes) Neu1 sialidase and its highly conserved enzymatic profiles with human
    Ryuzono, Sena
    Takase, Ryo
    Oishi, Kazuki
    Ikeda, Asami
    Chigwechokha, Petros Kingstone
    Funahashi, Aki
    Komatsu, Masaharu
    Miyagi, Taeko
    Shiozaki, Kazuhiro
    GENE, 2016, 575 (02) : 513 - 523
12345