Functioning, clinical severity, education and sex moderate the inverse relationship between insight and quality of life in patients with schizophrenia

被引:1
作者
Barbalat, Guillaume [1 ,2 ]
Marechal, Lisa [3 ,4 ]
Plasse, Julien [1 ,2 ]
Chereau-Boudet, Isabelle [5 ]
Gouache, Benjamin [6 ]
Legros-Lafarge, Emilie [7 ]
Massoubre, Catherine [8 ]
Guillard-Bouhet, Nathalie [9 ]
Haesebaert, Frederic [1 ,2 ]
Franck, Nicolas [1 ,2 ]
机构
[1] Ctr Natl Rech Sci CNRS, Hop Vinatier, Ctr Ressource Rehabil Psychosociale & Remediat Cog, Lyon, France
[2] Univ Lyon, Lyon, France
[3] CHU, Ctr Hosp Henri Laborit, Unite Rech Clin Pierre Deniker, Poitiers, France
[4] Fac Med Poitiers, Poitiers, France
[5] Ctr Hosp Univ Clermont Ferrand, Ctr Referent Conjoint Rehabil CRCR, Clermont Ferrand, France
[6] Ctr Hosp Alpes Isere, Ctr Referent Rehabil Psychosociale & Remediat Cogn, Grenoble, France
[7] Ctr Referent Rehabil Psychosociale Limoges C2RL, Limoges, France
[8] Ctr Hosp Univ St Etienne, Ctr Rehabil Psychosociale, REHALise, St Etienne, France
[9] Ctr Hosp Laborit, Ctr Rehabil Act Therapeut Intersectoriel Vienne CR, Poitiers, France
关键词
Schizophrenia; Insight; Quality of life; Insight paradox; Rehabilitation; Doubly-robust estimation; 1ST-EPISODE PSYCHOSIS; SELF-ESTEEM; COGNITIVE INSIGHT; DEPRESSION; PEOPLE; SYMPTOMS; PARADOX; STIGMA; DETERMINANTS; ASSOCIATION;
D O I
10.1016/j.schres.2023.12.015
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: In schizophrenia, insight, the recognition that one has a medical illness that requires treatment, has long been related to deteriorated quality of life, a phenomenon that has been described as the "insight paradox". Here, we aimed to determine whether certain socio-demographic and clinical characteristics strengthen or weaken this negative relationship.Methods: We used data from the French network of rehabilitation centers REHABase (N = 769). We explored mean differences in quality-of-life scores between patients with good insight vs. poor insight. We also explored modifying effects of socio-demographic and clinical characteristics (sex, education, age, functioning, clinical severity, duration of illness).Results: Patients with good insight had a decreased quality-of-life total score. Similar effects were found for the following sub-dimensions of quality of life: autonomy, physical and psychological well-being, and self-esteem. The negative effect of insight on quality of life was attenuated for people who had >12 years of education and for people with a higher level of functioning. By contrast, the negative effect of insight on quality of life was accentuated in people with greater clinical severity. Functioning and clinical severity showed similar modifying effects for other quality-of-life dimensions: autonomy, physical and psychological well-being, and self-esteem. Finally, males demonstrated an increased negative association between insight and self-esteem.Conclusions: The relationship between insight and quality of life is moderated by socio-demographic and clinical circumstances. Future inquiries may utilize our findings by integrating socio-demographic and clinical factors in treatment programs designs to conjointly improve insight and quality of life.
引用
收藏
页码:149 / 156
页数:8
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