Aerobic Training and Circulating Neurotrophins in Alzheimer's Disease Patients: A Controlled Trial

被引：10

作者：

Stein, Angelica Miki ^{[1
,2
,3
]}

de Melo Coelho, Flavia Gomes ^{[3
,4
]}

Vital-Silva, Thays Martins ^{[3
,5
]}

Rueda, Andre Veloso ^{[6
]}

Pereira, Jessica Rodrigues ^{[3
]}

Deslandes, Andrea Camaz ^{[7
]}

Camarini, Rosana ^{[6
]}

Santos Galduroz, Ruth Ferreira ^{[3
,8
]}

机构：

[1] UTFPR Univ Tecnol Fed Parana, Human Performance Res Grp, Curitiba, Parana, Brazil

[2] UFTM Univ Fed Triangulo Mineiro, Postgrad Program Phys Educ, Uberaba, Brazil

[3] Inst Fed Triangulo Mineiro, Patos De Minas, MG, Brazil

[4] Univ Sao Paulo, Biomed Sci Inst, Dept Pharmacol, Sao Paulo, Brazil

[5] UNESP Univ Estadual Paulista Julio de Mesquita Fi, Inst Biosci, Rio Claro, SP, Brazil

[6] UFRJ Univ Fed Rio de Janeiro, Inst Psychiat, Rio De Janeiro, RJ, Brazil

[7] UFABC Univ Fed ABC, Ctr Math Comp & Cognit, Sao Paulo, SP, Brazil

[8] Ufabc Univ Fed Abc, Santo Andre, SP, Brazil

来源：

EXPERIMENTAL AGING RESEARCH | 2023年 / 49卷 / 01期

关键词：

PHYSICAL-ACTIVITY; EXERCISE; MEMORY; PERFORMANCE; DEMENTIA; BRAIN; IGF-1; VEGF; BDNF; INTERVENTION;

D O I：

10.1080/0361073X.2022.2048586

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective to verify the effects of aerobic exercise training in circulating BDNF, VEGF(165) and IGF-1 plasma levels and cognitive function in Alzheimer's Disease (AD) patients. Methods 34 AD patients participated in the study, divided in two groups: Control Group (CG; n = 16) and Training Group (TG; n = 18 - Moderate aerobic training on the treadmill, three times a week, for 12 weeks). BDNF, VEGF(165,) and IGF-1 plasma levels were considered as a primary outcome. Secondary outcomes included cognitive functions and aerobic fitness. Results After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. For aerobic fitness, there was an increment in TG group. Conclusion Twelve weeks of aerobic training were neither effective in improving cognitive functioning significantly, nor influential on circulating neurotrophins levels in AD patients.

引用

页码：1 / 17

页数：17

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