Exosomes as a potential therapeutic approach in osteoimmunology

被引：3
|
作者：
Zhivodernikov, Ivan V. [1 ]
Markina, Yuliya V. [1 ]
Kirichenko, Tatiana V. [1 ]
Popov, Mikhail A. [2 ]
Markin, Alexander M. [1 ,3 ]
机构：
[1] Petrovsky Natl Res Ctr Surg, Lab Cellular & Mol Pathol Cardiovasc Syst, Moscow, Russia
[2] Moscow Reg Res & Clin Inst MONIKI, Dept Cardiac Surg, Moscow, Russia
[3] Peoples Friendship Univ Russia, Med Inst, Moscow 117198, Russia
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金：
俄罗斯科学基金会;
关键词：
exosomes; osteoimmunology; target therapy; immune system; osteoporosis; MESENCHYMAL STEM-CELLS; EXTRACELLULAR VESICLES; OSTEOBLASTS; MECHANISMS; REVERSAL; EFFICACY; TARGET;
D O I：
10.3389/fimmu.2023.1309015
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Exosomes are natural extracellular vesicles that play a key role in inter- and intracellular communication. Currently they are considered as a promising therapeutic strategy for the treatment of various diseases. In osteoimmunology, exosomes can serve as biomarkers of bone homeostasis disorders and, at the same time, promising therapeutic agents with high stability in the biological environment, low immunogenicity and good bioavailability. In this review, we attempted to examine exosomes as natural mediators of intercellular communication, playing an essential role in the interaction of the immune system and bone tissue, based on an analysis of the PubMed database up to October 2023.
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页数：8
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