Prevalence of Hepatocellular Carcinoma in Hepatitis B Population within Southeast Asia: A Systematic Review and Meta-Analysis of 39,050 Participants

被引：4

作者：

Rabaan, Ali A. ^{[1
,2
,3
]}

Bello, Kizito Eneye ^{[4
,5
]}

Irekeola, Ahmad Adebayo ^{[5
,6
]}

Al Kaabi, Nawal A. ^{[7
,8
]}

Halwani, Muhammad A. ^{[9
]}

Yousuf, Amjad A. ^{[10
]}

Alshengeti, Amer ^{[11
,12
]}

Alfaraj, Amal H. ^{[13
]}

Khamis, Faryal ^{[14
]}

Al-Subaie, Maha F. ^{[2
,15
,16
]}

Alshehail, Bashayer M. ^{[17
]}

Almuthree, Souad A. ^{[18
]}

Ibraheem, Noha Y. ^{[18
]}

Khalifa, Mahassen H. ^{[18
]}

Alfaresi, Mubarak ^{[19
,20
]}

Al Fares, Mona A. ^{[21
]}

Garout, Mohammed ^{[22
]}

Alsayyah, Ahmed ^{[23
]}

Alshehri, Ahmad A. ^{[24
]}

Alqahtani, Ali S. ^{[25
]}

Alissa, Mohammed ^{[26
]}

机构：

[1] Johns Hopkins Aramco Healthcare, Mol Diagnost Lab, Dhahran 31311, Saudi Arabia

[2] Alfaisal Univ, Coll Med, Riyadh 11533, Saudi Arabia

[3] Univ Haripur, Dept Publ Hlth & Nutr, Haripur 22610, Pakistan

[4] Prince Abubakar Audu Univ Anyigba, Kogi State Univ, Fac Nat Sci, Dept Microbiol, PMB 1008, Anyigba, Nigeria

[5] Univ Sains Malaysia, Sch Med Sci, Dept Med Microbiol & Parasitol, Hlth Campus, Kubang Kerian 16150, Kelantan, Malaysia

[6] Summit Univ Offa, Coll Nat & Appl Sci, Dept Biol Sci, Microbiol Unit, PMB 4412, Offa, Nigeria

[7] Khalifa Univ, Coll Med & Hlth Sci, Abu Dhabi, U Arab Emirates

[8] Abu Dhabi Hlth Serv Co SEHA, Sheikh Khalifa Med City, Abu Dhabi 51900, U Arab Emirates

[9] Al Baha Univ, Fac Med, Dept Med Microbiol, Al Baha 4781, Saudi Arabia

[10] Taibah Univ, Coll Appl Med Sci, Dept Med Labs Technol, Madinah 41411, Saudi Arabia

[11] Taibah Univ, Coll Med, Dept Pediat, Al Madinah 41491, Saudi Arabia

[12] Natl Guard Hlth Affairs, Prince Mohammad Bin Abdulaziz Hosp, Dept Infect Prevent & Control, Al Madinah 41491, Saudi Arabia

[13] Abqaiq Gen Hosp, Pediat Dept, Eastern Hlth Cluster 1, Abqaiq 33261, Saudi Arabia

[14] Royal Hosp, Dept Internal Med, Infect Dis Unit, Muscat 1331, Oman

[15] Dr Sulaiman Alhabib Med Grp, Res Ctr, Riyadh 13328, Saudi Arabia

[16] Dr Sulaiman Alhabib Med Grp, Dept Infect Dis, Riyadh 13328, Saudi Arabia

[17] Imam Abdulrahman Bin Faisal Univ, Coll Clin Pharm, Pharm Practice Dept, Dammam 31441, Saudi Arabia

[18] King Abdullah Med City, Dept Infect Dis, Mecca 43442, Saudi Arabia

[19] Zayed Mil Hosp, Dept Pathol & Lab Med, Abu Dhabi 3740, U Arab Emirates

[20] Mohammed Bin Rashid Univ Med & Hlth Sci, Coll Med, Dept Pathol, Dubai, U Arab Emirates

[21] King Abdulaziz Univ Hosp, Dept Internal Med, Jeddah 21589, Saudi Arabia

[22] Umm Al Qura Univ, Fac Med, Dept Community Med & Hlth Care Pilgrims, Mecca 21955, Saudi Arabia

[23] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Pathol, Dammam 31441, Saudi Arabia

[24] Najran Univ, Fac Appl Med Sci, Dept Clin Lab Sci, Najran 61441, Saudi Arabia

[25] King Khalid Univ, Fac Appl Med Sci, Dept Med Lab Sci, Abha 61481, Saudi Arabia

[26] Prince Sattam bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Kharj 11942, Saudi Arabia

来源：

PATHOGENS | 2023年 / 12卷 / 10期

关键词：

hepatocellular carcinoma; hepatitis B virus; liver disease; Southeast Asia; prevalence; systematic review; meta-analysis; PRIMARY LIVER-CANCER; RISK-FACTORS; VIRAL-HEPATITIS; SURVIVAL; ANTIGEN; EPIDEMIOLOGY; ASSOCIATION; HETEROGENEITY; EXPERIENCE; CIRRHOSIS;

D O I：

10.3390/pathogens12101220

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background and aim: Hepatocellular carcinoma (HCC) is a significant complication of hepatitis B and still poses a global public health concern. This systematic review and meta-analysis provide adequate details on the prevalence of HCC in the HBV population within Southeast Asian countries. Method: Following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) criteria, a thorough search for literature discussing the prevalence of HCC in the HBV population within southeast Asia was performed. Eligible studies were subjected to a meta-analysis utilising a DerSimonian and Laird approach and a random effect model. A protocol was registered with PROSPERO (CRD42023423953). Result: Our study meticulously recovered 41 articles from seven countries in Southeast Asia, namely Cambodia, Indonesia, Malaysia, the Philippines, Singapore, Thailand, and Vietnam. A total of 39,050 HBV patients and 7479 HCC cases in southeast Asia were analysed. The pooled prevalence of HCC in HBV cases within southeast Asia was 45.8% (95% CI, 34.3-57.8%, I-2 = 99.51%, p < 0.001). Singapore (62.5%, CI: 42.4-79.1) had the highest pooled prevalence of HCC in the HBV population compared to Vietnam, with the lowest estimate (22.4%, CI: 9.9-44.9). There was a drop in the pooled prevalence of HCC in HBV from 2016 until now (37.6%, CI: 19.2-60.5). Conclusion: The findings of this review reveal a high pooled prevalence of HCC in the HBV population and therefore stir the need for routine screening, management, and surveillance.

引用

页数：18

共 107 条

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