Continuous blood pressure monitoring by photoplethysmography-signal preprocessing requirements based on blood flow modelling

Objective. The aim of the study is to investigate the effect of the signal sampling frequency and low-pass filtering on the accuracy of the localisation of the fiducial points of the photoplethysmographic signal (PPG), and thus on the estimation of the blood pressure (i.e. the accuracy of the estimation). Approach. Statistical analysis was performed on 3,799 data samples taken from a publicly available database. Four PPG fiducial points of each sample signal were examined in the study. Main results. Simulation suggests that for noise-free data, cubic spline interpolation causes the sampling frequency (in the considered range of 62.5-500 Hz) to have only limited influence on localisation of the fiducial point. Better results were obtained for the pulse transit time (PTT) than pulse arrival time (PAT) approach. The acceptable filter band depends on the selected fiducial point and PAT or PTT approach. The best results were obtained for the tangent fiducial point. Significance. The presented results make it possible to estimate the minimum requirements for the sampling frequency and filtering of the PPG signal in order to obtain a reliable estimation of blood pressure.