共 64 条
Targeting EGFR and Monitoring Tumorigenesis of Human Lung Cancer Cells In Vitro and In Vivo Using Nanodiamond-Conjugated Specific EGFR Antibody
被引:3
作者:

Lin, Yu-Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Su, Hung-Cheng
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Raj, Emmanuel Naveen
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Inst Mol Med & Bioengn, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Liu, Kuang-Kai
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Chang, Chien-Jen
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan
Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Hsu, Tzu-Chia
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Cheng, Po-Yun
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Wang, Rou-Hsin
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan
Natl Yang Ming Chiao Tung Univ, Inst Mol Med & Bioengn, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Lai, Yen-Her
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Inst Mol Med & Bioengn, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Chen, Chien-Hung
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Lin, Yen-Cheng
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan

Chao, Jui-, I
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan
Natl Yang Ming Chiao Tung Univ, Inst Mol Med & Bioengn, Hsinchu 30068, Taiwan
Natl Yang Ming Chiao Tung Univ, Ctr Intelligent Drug Syst & Smart Biodevices, Hsinchu 30068, Taiwan Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan
机构:
[1] Natl Yang Ming Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu 30068, Taiwan
[2] Natl Yang Ming Chiao Tung Univ, Inst Mol Med & Bioengn, Hsinchu 30068, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Internal Med, Hsin Chu Branch, Hsinchu 30068, Taiwan
[4] Natl Yang Ming Chiao Tung Univ, Ctr Intelligent Drug Syst & Smart Biodevices, Hsinchu 30068, Taiwan
关键词:
nanodiamond;
cetuximab;
lung cancer therapy;
EGFR;
tumorigenesis;
EPIDERMAL-GROWTH-FACTOR;
FACTOR RECEPTOR;
FLUORESCENT NANODIAMOND;
MONOCLONAL-ANTIBODY;
ACQUIRED-RESISTANCE;
DRUG-DELIVERY;
NANOPARTICLES;
MUTATIONS;
CETUXIMAB;
TRACKING;
D O I:
10.3390/pharmaceutics15010111
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Nanoprobes provide advantages for real-time monitoring of tumor markers and tumorigenesis during cancer progression and development. Epidermal growth factor receptor (EGFR) is a key protein that plays crucial roles for tumorigenesis and cancer therapy of lung cancers. Here, we show a carbon-based nanoprobe, nanodiamond (ND), which can be applied for targeting EGFR and monitoring tumorigenesis of human lung cancer cells in vitro and in vivo. The optimal fluorescent intensities of ND particles were observed in the human lung cancer cells and nude mice under in vivo imaging system. The fluorescence signal of ND particles can be real-time detected in the xenografted human lung tumor formation of nude mice. Moreover, the ND-conjugated specific EGFR antibody cetuximab (Cet) can track the location and distribution of EGFR proteins of lung cancer cells in vitro and in vivo. ND-Cet treatment increased cellular uptake ability of nanocomposites in the EGFR-expressed cells but not in the EGFR-negative lung cancer cells. Interestingly, single ND-Cet complex can be directly observed on the protein G bead by immunoprecipitation and confocal microscopy. Besides, the EGFR proteins were transported to lysosomes for degradation. Together, this study demonstrates that ND-conjugated Cet can apply for targeting EGFR and monitoring tumorigenesis during lung cancer progression and therapy.
引用
收藏
页数:23
相关论文
共 64 条
[1]
Comparative Cytotoxic Evaluation of Zygophyllum album Root and Aerial Parts of Different Extracts and Their Biosynthesized Silver Nanoparticles on Lung A549 and Prostate PC-3 Cancer Cell Lines
[J].
Abdelhameed, Reda F. A.
;
Nafie, Mohamed S.
;
Hal, Dina M.
;
Nasr, Ali M.
;
Swidan, Shady A.
;
Abdel-Kader, Maged S.
;
Ibrahim, Amany K.
;
Ahmed, Safwat A.
;
Badr, Jihan M.
;
Eltamany, Enas E.
.
PHARMACEUTICALS,
2022, 15 (11)

Abdelhameed, Reda F. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt
Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Nafie, Mohamed S.
论文数: 0 引用数: 0
h-index: 0
机构:
Suez Canal Univ, Fac Sci, Dept Chem, Ismailia 41522, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Hal, Dina M.
论文数: 0 引用数: 0
h-index: 0
机构:
Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Nasr, Ali M.
论文数: 0 引用数: 0
h-index: 0
机构:
Port Said Univ, Fac Pharm, Dept Pharmaceut, Port Said 42526, Egypt
Galala Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, New Galala 43713, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Swidan, Shady A.
论文数: 0 引用数: 0
h-index: 0
机构:
British Univ Egypt, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, El Sherouk City 11837, Egypt
British Univ Egypt, Fac Pharm, Ctr Drug Res & Dev CDRD, El Sherouk City 11837, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Abdel-Kader, Maged S.
论文数: 0 引用数: 0
h-index: 0
机构:
Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacognosy, Al Kharj 11942, Saudi Arabia
Alexandria Univ, Fac Pharm, Dept Pharmacognosy, Alexandria 21215, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Ibrahim, Amany K.
论文数: 0 引用数: 0
h-index: 0
机构:
Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Ahmed, Safwat A.
论文数: 0 引用数: 0
h-index: 0
机构:
Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Badr, Jihan M.
论文数: 0 引用数: 0
h-index: 0
机构:
Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt

Eltamany, Enas E.
论文数: 0 引用数: 0
h-index: 0
机构:
Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia 41522, Egypt Galala Univ, Fac Pharm, Dept Pharmacognosy, New Galala 43713, Egypt
[2]
Adenosine Conjugated Docetaxel Nanoparticles-Proof of Concept Studies for Non-Small Cell Lung Cancer
[J].
Aldawsari, Hibah M.
;
Singh, Sima
;
Alhakamy, Nabil A.
;
Bakhaidar, Rana B.
;
Halwani, Abdulrahman A.
;
Sreeharsha, Nagaraja
;
Badr-Eldin, Shaimaa M.
.
PHARMACEUTICALS,
2022, 15 (05)

Aldawsari, Hibah M.
论文数: 0 引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia
King Abdulaziz Univ, Ctr Excellence Drug Res & Pharmaceut Ind, Jeddah 21589, Saudi Arabia King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia

论文数: 引用数:
h-index:
机构:

Alhakamy, Nabil A.
论文数: 0 引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia
King Abdulaziz Univ, Ctr Excellence Drug Res & Pharmaceut Ind, Jeddah 21589, Saudi Arabia King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia

Bakhaidar, Rana B.
论文数: 0 引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia

Halwani, Abdulrahman A.
论文数: 0 引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia

论文数: 引用数:
h-index:
机构:

Badr-Eldin, Shaimaa M.
论文数: 0 引用数: 0
h-index: 0
机构:
King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia
King Abdulaziz Univ, Ctr Excellence Drug Res & Pharmaceut Ind, Jeddah 21589, Saudi Arabia King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut, Jeddah 21589, Saudi Arabia
[3]
Near infrared imaging with nanoparticles
[J].
Altinoglu, Erhan I.
;
Adair, James H.
.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,
2010, 2 (05)
:461-477

Altinoglu, Erhan I.
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA

Adair, James H.
论文数: 0 引用数: 0
h-index: 0
机构:
Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA Penn State Univ, Dept Mat Sci & Engn, University Pk, PA 16802 USA
[4]
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
[J].
Ben-Porath, Ittai
;
Thomson, Matthew W.
;
Carey, Vincent J.
;
Ge, Ruping
;
Bell, George W.
;
Regev, Aviv
;
Weinberg, Robert A.
.
NATURE GENETICS,
2008, 40 (05)
:499-507

Ben-Porath, Ittai
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02142 USA
MIT, Ludwig Ctr Canc Res, Cambridge, MA 02142 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02142 USA

Thomson, Matthew W.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02142 USA
MIT, Broad Inst Harvard, Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02142 USA

Carey, Vincent J.
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Channing Lab, Brigham & Womens Hosp,Dana Farber Canc Inst, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Brigham & Womens Hosp,Dana Farber Canc Inst, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med, Brigham & Womens Hosp,Dana Farber Canc Inst, Boston, MA 02115 USA MIT, Dept Biol, Cambridge, MA 02142 USA

Ge, Ruping
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02142 USA

Bell, George W.
论文数: 0 引用数: 0
h-index: 0
机构:
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02142 USA

Regev, Aviv
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02142 USA
MIT, Broad Inst Harvard, Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02142 USA

Weinberg, Robert A.
论文数: 0 引用数: 0
h-index: 0
机构:
MIT, Dept Biol, Cambridge, MA 02142 USA
MIT, Ludwig Ctr Canc Res, Cambridge, MA 02142 USA
Whitehead Inst Biomed Res, Cambridge, MA 02142 USA MIT, Dept Biol, Cambridge, MA 02142 USA
[5]
Noncovalent Functionalization of Carbon Nanovectors with an Antibody Enables Targeted Drug Delivery
[J].
Berlin, Jacob M.
;
Pham, Tam T.
;
Sano, Daisuke
;
Mohamedali, Khalid A.
;
Marcano, Daniela C.
;
Myers, Jeffrey N.
;
Tour, James M.
.
ACS NANO,
2011, 5 (08)
:6643-6650

Berlin, Jacob M.
论文数: 0 引用数: 0
h-index: 0
机构:
Rice Univ, Dept Chem, Houston, TX 77005 USA Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA

Pham, Tam T.
论文数: 0 引用数: 0
h-index: 0
机构:
Rice Univ, Dept Chem, Houston, TX 77005 USA Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA

Sano, Daisuke
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA

Mohamedali, Khalid A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Unit 1950, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA

Marcano, Daniela C.
论文数: 0 引用数: 0
h-index: 0
机构:
Rice Univ, Dept Chem, Houston, TX 77005 USA Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA

Myers, Jeffrey N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA

Tour, James M.
论文数: 0 引用数: 0
h-index: 0
机构:
Rice Univ, Dept Chem, Houston, TX 77005 USA
Rice Univ, Smalley Inst Nanoscale Sci & Technol, Houston, TX 77005 USA Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 441, Houston, TX 77030 USA
[6]
Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis
[J].
Bhattacharyya, Sanjib
;
Bhattacharya, Resham
;
Curley, Steven
;
McNiven, Mark A.
;
Mukherjee, Priyabrata
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2010, 107 (33)
:14541-14546

Bhattacharyya, Sanjib
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

Bhattacharya, Resham
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

Curley, Steven
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, MD Anderson Canc Ctr, Dept Surg, Houston, TX 77030 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

McNiven, Mark A.
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
Mayo Clin, Ctr Canc, Rochester, MN 55905 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

Mukherjee, Priyabrata
论文数: 0 引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
Mayo Clin, Dept Biomed Engn, Rochester, MN 55905 USA
Mayo Clin, Ctr Canc, Rochester, MN 55905 USA Mayo Clin, Dept Biochem & Mol Biol, Rochester, MN 55905 USA
[7]
Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab
[J].
Brand, Toni M.
;
Iida, Mari
;
Wheeler, Deric L.
.
CANCER BIOLOGY & THERAPY,
2011, 11 (09)
:777-792

Brand, Toni M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Human Oncol, Sch Med & Publ Hlth, Madison, WI 53706 USA Univ Wisconsin, Dept Human Oncol, Sch Med & Publ Hlth, Madison, WI 53706 USA

Iida, Mari
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Human Oncol, Sch Med & Publ Hlth, Madison, WI 53706 USA Univ Wisconsin, Dept Human Oncol, Sch Med & Publ Hlth, Madison, WI 53706 USA

Wheeler, Deric L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Dept Human Oncol, Sch Med & Publ Hlth, Madison, WI 53706 USA Univ Wisconsin, Dept Human Oncol, Sch Med & Publ Hlth, Madison, WI 53706 USA
[8]
Mass production and dynamic imaging of fluorescent nanodiamonds
[J].
Chang, Yi-Ren
;
Lee, Hsu-Yang
;
Chen, Kowa
;
Chang, Chun-Chieh
;
Tsai, Dung-Sheng
;
Fu, Chi-Cheng
;
Lim, Tsong-Shin
;
Tzeng, Yan-Kai
;
Fang, Chia-Yi
;
Han, Chau-Chung
;
Chang, Huan-Cheng
;
Fann, Wunshain
.
NATURE NANOTECHNOLOGY,
2008, 3 (05)
:284-288

Chang, Yi-Ren
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Lee, Hsu-Yang
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Chen, Kowa
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Chang, Chun-Chieh
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Tsai, Dung-Sheng
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Fu, Chi-Cheng
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Lim, Tsong-Shin
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Tzeng, Yan-Kai
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Fang, Chia-Yi
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan
Natl Taiwan Normal Univ, Dept Chem, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Han, Chau-Chung
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Chang, Huan-Cheng
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan
Natl Taiwan Normal Univ, Dept Chem, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan

Fann, Wunshain
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan
Natl Taiwan Univ, Dept Phys, Taipei 106, Taiwan
Natl Taiwan Univ, Inst Polymer Sci & Engn, Taipei 106, Taiwan Acad Sinica, Inst Atom & Mol Sci, Taipei 106, Taiwan
[9]
Nanometer-sized diamond particle as a probe for biolabeling
[J].
Chao, Jui-I.
;
Perevedentseva, Elena
;
Chung, Pei-Hua
;
Liu, Kuang-Kai
;
Cheng, Chih-Yuan
;
Chang, Chia-Ching
;
Cheng, Chia-Liang
.
BIOPHYSICAL JOURNAL,
2007, 93 (06)
:2199-2208

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Chung, Pei-Hua
论文数: 0 引用数: 0
h-index: 0
机构: Natl Dong Hwa Univ, Dept Phys, Hualien 97401, Taiwan

Liu, Kuang-Kai
论文数: 0 引用数: 0
h-index: 0
机构: Natl Dong Hwa Univ, Dept Phys, Hualien 97401, Taiwan

Cheng, Chih-Yuan
论文数: 0 引用数: 0
h-index: 0
机构: Natl Dong Hwa Univ, Dept Phys, Hualien 97401, Taiwan

Chang, Chia-Ching
论文数: 0 引用数: 0
h-index: 0
机构: Natl Dong Hwa Univ, Dept Phys, Hualien 97401, Taiwan

Cheng, Chia-Liang
论文数: 0 引用数: 0
h-index: 0
机构: Natl Dong Hwa Univ, Dept Phys, Hualien 97401, Taiwan
[10]
Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation
[J].
Chiou, Shih-Hwa
;
Wang, Mong-Lien
;
Chou, Yu-Ting
;
Chen, Chi-Jen
;
Hong, Chun-Fu
;
Hsieh, Wang-Ju
;
Chang, Hsin-Tzu
;
Chen, Ying-Shan
;
Lin, Tzu-Wei
;
Hsu, Han-Sui
;
Wu, Cheng-Wen
.
CANCER RESEARCH,
2010, 70 (24)
:10433-10444

Chiou, Shih-Hwa
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan
Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan
Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

论文数: 引用数:
h-index:
机构:

Chou, Yu-Ting
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Biomed Sci, Taipei, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

Chen, Chi-Jen
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Biomed Sci, Taipei, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

Hong, Chun-Fu
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Biomed Sci, Taipei, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

Hsieh, Wang-Ju
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Microbiol & Immunol, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

Chang, Hsin-Tzu
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

Chen, Ying-Shan
论文数: 0 引用数: 0
h-index: 0
机构:
Acad Sinica, Inst Biomed Sci, Taipei, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

Lin, Tzu-Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

Hsu, Han-Sui
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan
Taipei Vet Gen Hosp, Dept Surg, Taipei, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan

Wu, Cheng-Wen
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan
Natl Yang Ming Univ, Inst Microbiol & Immunol, Taipei 112, Taiwan
Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan
Acad Sinica, Inst Biomed Sci, Taipei, Taiwan Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 112, Taiwan