In vitro DNA damage prevention, antioxidant and antidiabetic activities of achillea biebersteinii/millefolium extracts and synthesized ZnO nanoparticles

Aim: In this study, DNA damage preventive effects, antioxidant and antidiabetic activities of extracts of Achillea species growing endemic in the Lapta region of Kyrenia district of Cyprus, and zinc oxide-nanoparticles/Achillea (ZnO-NPs/Ach) were investigated. Material and Methods: We performed green synthesis of ZnO-Nps using the extract obtained from Achillea species (ZnO-NPs/Ach). We performed green synthesis of ZnO-Nps using the extract obtained from Achillea species (ZnO-NPs/Ach). Additionally, we determined the anti -DNA damage, antioxidant, and antidiabetic activities of these nanoparticles. Results: The highest concentration of 500 mu g/mL of ZnO-NPs/Ach had an excellent protective effect. It was determined that the activity of ZnO-NPs/Ach was relatively vigorous in preventing lipid peroxidation. The lipid peroxidation inhibitory activities of ZnO-NPs/A. biebersteinii and ZnO-NPs/A. millefolium were calculated as 90.87% and 89.11%, respectively. Additionally, both demonstrated high antidiabetic effects compared to the positive control acarbose. Discussion: As zinc oxide nanoparticles obtained through green synthesis have been found to have preventive effects on DNA damage, as well as antioxidant and antidiabetic properties, this study is expected to make a valuable contribution to the medical and technological literature.