Iodine Mediated One-Pot Synthesis of Polyarylated-Oxazoles from Internal Alkynes

被引：0
作者：
Adhikary, Saswati [1 ]
Banerji, Biswadip [1 ,2 ]
机构：
[1] Indian Inst Chem Biol CSIR IICB, Organ & Med Chem Div, 4 Raja SC Mullick Rd, Kolkata 700032, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
来源：
CHEMISTRYSELECT | 2023年 / 8卷 / 23期
关键词：
One-pot synthesis; Highlysubstituted oxazole; Alkyne annulation; Transition metal free; Iodine; C-H FUNCTIONALIZATION; METAL-FREE; DERIVATIVES; CYCLIZATION; WATER;
D O I：
10.1002/slct.202300076
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An environmentally benign, efficient, practically applicable and C(sp(3))-H functionalization of primary amines for the synthesis of highly substituted oxazoles from easily available internal alkynes was developed. This synthesis is toxic chemicals, transition-metal free as well as mild and regioselective. This one-pot methodology with broad substrate scope unlocks a green avenue for the synthesis of highly functionalized oxazole derivatives with excellent yields.
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页数：6
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