Osteoarthritis Bone Marrow Lesions

被引：33

作者：

Walsh, D. A. ^{[1
,2
]}

Sofat, N. ^{[3
,4
]}

Guermazi, A. ^{[5
]}

Hunter, D. J. ^{[6
,7
]}

机构：

[1] Univ Nottingham Clin Sci Bldg, City Hosp, Pain Ctr Versus Arthrit, NIHR Nottingham Biomed Res Ctr,Acad Rheumatol,Sch, Hucknall Rd, Nottingham NG51PB, England

[2] Sherwood Forest Hosp NHS Fdn Trust, Mansfield Rd, Sutton In Ashfield NG174JL, England

[3] St Georges Univ London, Inst Infect & Immun, London SW17OR, England

[4] St Georges Univ Hosp NHS Trust, London SW17OPQ, England

[5] Boston Univ, Sch Med, Dept Radiol, VA Boston Hlthcare Syst, Boston, MA USA

[6] Univ Sydney, Kolling Inst, Sydney Musculoskeletal Hlth, Sydney, Australia

[7] Royal North Shore Hosp, Rheumatol Dept, Sydney, Australia

来源：

OSTEOARTHRITIS AND CARTILAGE | 2023年 / 31卷 / 01期

关键词：

Bone-marrow-lesion; Magnetic-resonance-imaging; Pain; Disease-modifying-osteoarthritis-drugs; TIBIOFEMORAL CARTILAGE VOLUME; KNEE OSTEOARTHRITIS; SUBCHONDRAL BONE; ZOLEDRONIC ACID; NERVE GROWTH; PAIN; ASSOCIATION; MRI; ANGIOGENESIS; PROGRESSION;

D O I：

10.1016/j.joca.2022.09.007

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Assessment and treatment of Bone Marrow Lesions (BMLs) could ultimately make step changes to the lives of people with osteoarthritis (OA). We here review the imaging and pathological characteristics of OA-BMLs, their differential diagnosis and measurement, and cross-sectional and longitudinal associa-tions with pain and OA structural progression. We discuss how biomechanical and cellular factors may contribute to BML pathogenesis, and how pharmacological and non-pharmacological interventions that target BMLs might reduce pain and OA structural progression. We critically appraise semiquantitative and quantitative methods for assessing BMLs, and their potential utilities for identifying people at risk of symptomatic and structural OA progression, and evaluating treatment responses. New interventions that target OA-BMLs should both confirm their importance, and reduce the unacceptable burden of OA. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY license (http://creativecommons.org/ licenses/by/4.0/).

引用

页码：11 / 17

页数：7

共 51 条

[1] Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative [J].