Linking early-life bilingualism and cognitive advantage in older adulthood

被引：5

作者：

Ballarini, Tommaso ^{[1
]}

Kuhn, Elizabeth ^{[1
]}

Roeske, Sandra ^{[1
]}

Altenstein, Slawek ^{[2
,3
]}

Bartels, Claudia ^{[4
]}

Buchholz, Friederike ^{[5
]}

Buerger, Katharina ^{[6
,7
]}

Dechent, Peter ^{[8
]}

Dobisch, Laura ^{[9
,29
]}

Ewers, Michael ^{[6
,7
]}

Fliessbach, Klaus ^{[1
,10
]}

Freiesleben, Silka Dawn ^{[2
,5
]}

Frommann, Ingo ^{[1
,10
,13
]}

Gabelin, Tatjana ^{[5
]}

Glanz, Wenzel ^{[9
]}

Goerss, Doreen ^{[11
]}

Haynes, John Dylan ^{[12
]}

Incesoy, Enise I. ^{[9
]}

Janowitz, Daniel ^{[7
]}

Kilimann, Ingo ^{[11
]}

Kleineidam, Luca ^{[1
]}

Kobeleva, Xenia ^{[1
]}

Laske, Christoph ^{[14
,15
,16
]}

Lohse, Andrea ^{[3
]}

Maier, Franziska ^{[17
]}

Munk, Matthias H. ^{[14
,15
,16
]}

Perneczky, Robert ^{[6
,18
,19
,20
]}

Peter, Oliver ^{[2
,5
]}

Priller, Josef ^{[2
,3
,21
,22
,23
]}

Rauchman, Boris-Stephan ^{[18
]}

Roy, Nina ^{[1
]}

Scheffler, Klaus ^{[24
]}

Schneider, Anja ^{[1
,10
]}

Schott, Bjorn H. ^{[4
,25
,26
]}

Spottke, Annika ^{[1
,27
]}

Sprut, Eike Jakob ^{[2
,3
]}

Teipel, Stefan ^{[13
]}

Wiltfang, Jens ^{[4
,25
,28
]}

Wolfsgruber, Steffen ^{[1
,10
]}

Duezel, Emrah ^{[9
,29
]}

Jessen, Frank ^{[1
,17
,30
]}

Wagner, Michael ^{[1
,10
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Venusberg Campus 1, D-53127 Bonn, Germany

[2] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[3] Charite, Dept Psychiat & Psychotherapy, Berlin, Germany

[4] Univ Goettingen, Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[5] Charite Univ Med Berlin, Dept Psychiat, Berlin, Germany

[6] German Ctr Neurodegenerat Dis DZNE, Munich, Germany

[7] LMU, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany

[8] Georg August Univ Goettingen, Dept Cognit Neurol, MR Res Neurosci, Gottingen, Germany

[9] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[10] Univ Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat Psychi, Med Ctr, Bonn, Germany

[11] Rostock Univ, Dept Psychosomat Med, Med Ctr, Rostock, Germany

[12] Charite, Bernstein Ctr Computat Neurosci, Berlin, Germany

[13] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[14] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[15] Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Tubingen, Germany

[16] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[17] Univ Cologne, Med Fac, Dept Psychiat, Cologne, Germany

[18] LMU, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany

[19] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[20] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit AGE, London, England

[21] Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany

[22] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[23] UK DRI, Edinburgh, Midlothian, Scotland

[24] Univ Tubingen, Dept Biomed Magnet Resonance, Tubingen, Germany

[25] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[26] Leibniz Inst Neurobiol, Magdeburg, Germany

[27] Univ Bonn, Dept Neurol, Bonn, Germany

[28] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal

[29] Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

[30] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

来源：

NEUROBIOLOGY OF AGING | 2023年 / 124卷

关键词：

Bilingualism; Brain structure; Voxel-based-morphometry; Aging; Neuropsychology; DEMENTIA; BRAIN; AGE; QUESTIONNAIRE; CONNECTIVITY; ACQUISITION; PLASTICITY; PROTECTS; RESERVE; MEMORY;

D O I：

10.1016/j.neurobiolaging.2022.12.005

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Previous studies have identified bilingualism as a protective factor against dementia. Here we aimed to test whether being bilingual at different life stages impacts cognition and brain structure in older adult-hood. We included 746 participants from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). Assessment of bilingualism at 3 life stages (early: 13-30, middle: 30-65 and late: over 65 years old) was determined with the Lifetime of Experiences Questionnaire. Individuals reporting bilin-gualism (i.e., daily use of L2) in the early life stage outperformed monolinguals on learning & memory, working-memory, executive functions and language. Bilingualism in middle life stage showed a signifi-cant advantage on learning & memory, while no effect of bilingualism in old life stage was identified. Brain gray matter volume was not associated with L2 use and did not differ between groups. However, stronger correlations between brain gray matter volume in selected brain regions and cognitive perfor-mance were found in bilingual participants in the early and middle life stages. Our results indicate that bilingualism in early life might provide a long-lasting protective effect on cognition and shape the brain to sustain cognitive performance in older adulthood. (c) 2022 Elsevier Inc. All rights reserved.

引用

页码：18 / 28

页数：11

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