Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1α/VEGF/eNOS/NO signal pathway

被引：25

作者：

Long, Yu ^{[1
]}

Liu, Songyu ^{[1
]}

Wan, Jinyan

Zhang, Yulu ^{[1
]}

Li, Dan ^{[1
]}

Yu, Shuang

Shi, Ai ^{[1
]}

Li, Nan ^{[1
]}

He, Fei ^{[2
]}

机构：

[1] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, 1166, Liutai Ave, Chengdu 611137, Peoples R China

[2] Chongqing Med Univ, Yongchuan Hosp, 439, Xuanhua Rd, Chongqing 402160, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 160卷

关键词：

Cerebral ischemia-reperfusion injury; Borneol-baicalin liposome; Blood -brain barrier; Pharmacodynamics; Pharmacokinetics; MODEL;

D O I：

10.1016/j.biopha.2023.114240

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Baicalin (BA) is widely used in the treatment of cerebral ischemia-reperfusion injury (CIRI). The key to treating encephalopathy is to increase the amounts of drugs entering the brain. Borneol-baicalin liposome (BO-BA-LP) was prepared in previous research based on the characteristics of borneol (BO) in promoting drug brain entry. In this study, the effect of BO-BA-LP on improving blood-brain barrier (BBB) integrity was researched. Results showed BO-BA-LP may increase ability of BA to penetrate the cell membrane in vitro. Pharmacokinetic results showed the BO-BA-LP could increase concentrations of BA in plasma and brain tissues of normal and CIRI mice. Pharmacological results revealed BO-BA-LP could improve the neurological function, brain edema, and histopathology of CIRI mice. Besides, BO-BA-LP could protect BBB by regulating hypoxia inducible factor-1 alpha (HIF1 alpha)/vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS)/nitric oxide (NO) pathway. The research showed that BO in BO-BA-LP could increase the absorption of BA by increasing BBB permeability, leading to a better therapeutic effect of BO-BA-LP on CIRI mice.

引用

页数：9

共 29 条

[1] The blood-brain barrier: an overview - Structure, regulation, and clinical implications [J].

Ballabh, P ;

Braun, A ;

Nedergaard, M .

NEUROBIOLOGY OF DISEASE, 2004, 16 (01) :1-13

[2] Suppression of Hypoxia-Inducible Factor-1α and Its Downstream Genes Reduces Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Rat Model of Cerebral Ischemia [J].

Chen, Chunhua ;

Ostrowski, Robert P. ;

Zhou, Changman ;

Tang, Jiping ;

Zhang, John H. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2010, 88 (09) :2046-2055

[3] Early inhibition of HIF-1α with small interfering RNA reduces ischemic-reperfused brain injury in rats [J].

Chen, Chunhua ;

Hu, Qin ;

Yan, Junhao ;

Yang, Xiaomei ;

Shi, Xianzhong ;

Lei, Jiliang ;

Chen, Lin ;

Huang, Hongyun ;

Han, Jingyan ;

Zhang, John H. ;

Zhou, Changman .

NEUROBIOLOGY OF DISEASE, 2009, 33 (03) :509-517

[4] Propofol improved hypoxia-impaired integrity of blood-brain barrier via modulating the expression and phosphorylation of zonula occludens-1 [J].

Chen, Wei ;

Ju, Xing-Zhu ;

Lu, Yan ;

Ding, Xiao-Wei ;

Miao, Chang-Hong ;

Chen, Jia-Wei .

CNS NEUROSCIENCE & THERAPEUTICS, 2019, 25 (06) :704-713

[5] Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases [J].

Furtado, Denzil ;

Bjornmalm, Mattias ;

Ayton, Scott ;

Bush, Ashley I. ;

Kempe, Kristian ;

Caruso, Frank .

ADVANCED MATERIALS, 2018, 30 (46)

[6] VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling [J].

Heinolainen, Krista ;

Karaman, Sinem ;

D'Amico, Gabriela ;

Tammela, Tuomas ;

Sormunen, Raija ;

Eklund, Lauri ;

Alitalo, Kari ;

Zarkada, Georgia .

CIRCULATION RESEARCH, 2017, 120 (09) :1414-+

[7] Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke [J].

Hu, Xiaoming ;

De Silva, T. Michael ;

Chen, Jun ;

Faraci, Frank M. .

CIRCULATION RESEARCH, 2017, 120 (03) :449-471

[8] Optimization of the Ultrasound-Induced Blood-Brain Barrier Opening [J].

Konofagou, Elisa E. .

THERANOSTICS, 2012, 2 (12) :1223-1237

[9] Synthesis and Anti-Inflammatory Activities of Phloroglucinol-Based Derivatives [J].

Li, Ning ;

Khan, Shabana I. ;

Qiu, Shi ;

Li, Xing-Cong .

MOLECULES, 2018, 23 (12)

[10] Progress in Borneol Intervention for Ischemic Stroke: A Systematic Review [J].

Li, Yong ;

Ren, Mihong ;

Wang, Jiajun ;

Ma, Rong ;

Chen, Hai ;

Xie, Qian ;

Li, Hongyan ;

Li, Jinxiu ;

Wang, Jian .

FRONTIERS IN PHARMACOLOGY, 2021, 12

← 1 2 3 →