Eggs for Improving Nutrition, cognitive development and reducing linear growth retardation among Infants and young Children (ENRICH): protocol of an egg supplementation trial among children aged 9-18 months in Hyderabad, India

被引：0

作者：

Banjara, Santosh Kumar ^{[1
]}

Challa, Sai Ram ^{[1
]}

Augustine, Little Flower ^{[1
]}

Dasi, Teena ^{[1
]}

Madhari, Radhika ^{[1
]}

Rao, Sylvia Fernandez ^{[1
]}

Palika, Ravindranadh ^{[1
]}

Pullakhandam, Raghu ^{[1
]}

Kalashikam, Rajender Rao ^{[1
]}

Kumar, Ramachandrappa Naveen ^{[1
]}

Palepu, Dharani Pratyusha ^{[1
]}

Chilumula, Monica ^{[1
]}

Selvaraj, Kiruthika ^{[1
]}

Gopinath, Preethi ^{[1
]}

Davies-Kershaw, Hilary ^{[2
]}

Jobarteh, Modou Lamin ^{[3
]}

Haggarty, Paul ^{[4
]}

Heffernan, Claire ^{[5
,6
]}

Ferguson, Elaine ^{[7
]}

Kulkarni, Bharati ^{[1
]}

机构：

[1] ICMR Natl Inst Nutr, Hyderabad, India

[2] Dept Populat Hlth, LSHTM, London, England

[3] London Sch Hyg & Trop Med, Epidemiol & Populat Hlth, London, England

[4] Univ Aberdeen, Aberdeen, Scotland

[5] Univ London, Royal Vet Coll, London, England

[6] London Int Dev Ctr LIDC, London, England

[7] London Sch Hyg & Trop Med LSHTM, London, England

来源：

BMJ PAEDIATRICS OPEN | 2024年 / 8卷 / SUPPL_1期

基金：

英国科研创新办公室;

关键词：

Nutrition; Epidemiology; Growth; Child Psychiatry; Health services research; COMPLEMENTARY;

D O I：

10.1136/bmjpo-2023-001892

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Introduction Evidence on the impact of nutrient-rich animal source foods such as eggs for improving child growth and cognition is inconsistent. This study aims to examine the impact of an egg intervention in children, along with behaviour change communication (BCC) to the mother, on linear growth and cognition, and nutritional status in children aged 9-18 months.Methods and analysis A 9-month open-labelled randomised controlled trial will be conducted in three urban slums in Hyderabad, India, as a substudy of an observational cohort study (n=350) following pregnant women and their children until 18 months of age in a population at risk of stunting. The children born to women enrolled during the third trimester of pregnancy will be block randomised in a 1:4 ratio into the intervention (n=70) and control (n=280) groups. Children in the intervention group will be supplemented with one egg per day starting from 9 months until 18 months of age. BCC designed to enhance adherence to the intervention will be used. The control group will be a part of the observational cohort and will not receive any intervention from the study team. The primary outcome will be length-for-age z-scores, and the secondary outcomes will include cognition, blood biomarkers of nutritional status including fatty acid profile and epigenetic signatures linked with linear growth and cognition. Multivariate intention-to-treat analyses will be conducted to assess the effect of the intervention.Ethics and dissemination The study is approved by the Institutional ethics committees of ICMR-National Institute of Nutrition, Hyderabad, India and London School of Hygiene and Tropical Medicine, UK. The results will be published in peer-reviewed journals and disseminated to policy-makers. Findings will also be shared with study participants and community leaders.Trial registration number CTRI/2021/11/038208

引用

页数：8

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