CAR T-cell therapy in multiple myeloma: mission accomplished?

被引：20

作者：

Rasche, Leo ^{[1
,2
]}

Hudecek, Michael ^{[1
,3
]}

Einsele, Hermann ^{[1
,4
]}

机构：

[1] Univ Klinikum Wurzburg, Med Klin & Poliklin 2, Wurzburg, Germany

[2] Univ Klinikum Wurzburg, Mildred Scheel Early Career Ctr, Wurzburg, Germany

[3] Univ Klinikum Wurzburg, Lehrstuhl Zellulare Immuntherapie, Med Klin & Poliklin 2, Wurzburg, Germany

[4] Univ Klinikum Wurzburg, Med Klin & Poliklin 2, Oberdurrbacherstr 6, D-97080 Wurzburg, Germany

来源：

BLOOD | 2024年 / 143卷 / 04期

关键词：

CILTACABTAGENE AUTOLEUCEL; TRANSPLANTATION; LYMPHOMA; EFFICACY; SAFETY;

D O I：

10.1182/blood.2023021221

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells are the most potent treatment against multiple myeloma (MM). Here, we review the increasing body of clinical and correlative preclinical data that support their inclusion into firstline therapy and sequencing before T-cell-engaging antibodies. The ambition to cure MM with (BCMA-)CAR T cells is informed by genomic and phenotypic analysis that assess BCMA expression for patient stratification and monitoring, steadily improving early diagnosis and management of side effects, and advances in rapid, scalable CAR T-cell manufacturing to improve access.

引用

页码：305 / 310

页数：6

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