Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

被引：6

作者：

Jumaniyazova, Enar ^{[1
]}

Lokhonina, Anastasiya ^{[1
,2
,3
]}

Dzhalilova, Dzhuliia ^{[1
,2
]}

Kosyreva, Anna ^{[1
,2
]}

Fatkhudinov, Timur ^{[1
,2
]}

机构：

[1] Peoples Friendship Univ Russia, Res Inst Mol & Cellular Med, RUDN Univ, 6 Miklukho Maklaya St, Moscow 117198, Russia

[2] FSBSI Petrovsky Natl Res Ctr Surg, Avtsyn Res Inst Human Morphol, 3 Tsyurupy St, Moscow 117418, Russia

[3] Minist Healthcare Russian Federat, Natl Med Res Ctr Obstet Gynecol & Perinatol, 4 Oparina St, Moscow 117997, Russia

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 11期

基金：

俄罗斯科学基金会;

关键词：

head and neck squamous cell carcinoma; HNSCC; tumor microenvironments; hypoxia in the TME; cancer-associated fibroblasts; vascular component; extracellular matrix; ENDOTHELIAL GROWTH-FACTOR; CANCER-ASSOCIATED FIBROBLASTS; EPITHELIAL-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTORS; ENHANCED TUMOR-GROWTH; INTEGRIN ALPHA-V; EXTRACELLULAR-MATRIX; PROGNOSTIC-SIGNIFICANCE; SIGNALING PATHWAY; GENE-EXPRESSION;

D O I：

10.3390/jpm13111616

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Head and neck squamous cell cancer (HNSCC) is one of the ten most common malignant neoplasms, characterized by an aggressive course, high recurrence rate, poor response to treatment, and low survival rate. This creates the need for a deeper understanding of the mechanisms of the pathogenesis of this cancer. The tumor microenvironment (TME) of HNSCC consists of stromal and immune cells, blood and lymphatic vessels, and extracellular matrix. It is known that HNSCC is characterized by complex relationships between cancer cells and TME components. TME components and their dynamic interactions with cancer cells enhance tumor adaptation to the environment, which provides the highly aggressive potential of HNSCC and resistance to antitumor therapy. Basic research aimed at studying the role of TME components in HNSCC carcinogenesis may serve as a key to the discovery of both new biomarkers-predictors of prognosis and targets for new antitumor drugs. This review article focuses on the role and interaction with cancer of TME components such as newly formed vessels, cancer-associated fibroblasts, and extracellular matrix.

引用

页数：25

共 266 条

[1] A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation [J].

Abrahao, Aline Correa ;

Castilho, Rogerio M. ;

Squarize, Cristiane H. ;

Molinolo, Alfredo A. ;

dos Santos-Pinto, Decio, Jr. ;

Gutkind, J. Silvio .

ORAL ONCOLOGY, 2010, 46 (12) :880-887

[2] Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration [J].

Acerbi, I. ;

Cassereau, L. ;

Dean, I. ;

Shi, Q. ;

Au, A. ;

Park, C. ;

Chen, Y. Y. ;

Liphardt, J. ;

Hwang, E. S. ;

Weaver, V. M. .

INTEGRATIVE BIOLOGY, 2015, 7 (10) :1120-1134

[3] Expression of vascular endothelial growth factor (VEGF) in patients with oral squamous cell carcinoma and its clinical significance [J].

Aggarvval, Sadhna ;

Devaraja, K. ;

Sharma, Suresh C. ;

Das, Satya N. .

CLINICA CHIMICA ACTA, 2014, 436 :35-40

[4] Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2 [J].

Alcolea, Sonia ;

Anton, Rosa ;

Camacho, Mercedes ;

Soler, Marta ;

Alfranca, Arantzazu ;

Aviles-Jurado, Francesc-Xavier ;

Redondo, Juan-Miguel ;

Quer, Miquel ;

Leon, Xavier ;

Vila, Luis .

JOURNAL OF LIPID RESEARCH, 2012, 53 (04) :630-642

[5] Clinical significance of tumor-stroma ratio in head and neck cancer: a systematic review and meta-analysis [J].

Almangush, Alhadi ;

Alabi, Rasheed Omobolaji ;

Troiano, Giuseppe ;

Coletta, Ricardo D. ;

Salo, Tuula ;

Pirinen, Matti ;

Makitie, Antti A. ;

Leivo, Ilmo .

BMC CANCER, 2021, 21 (01)

[6] Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets [J].

Alvarez-Teijeiro, Saul ;

Garcia-Inclan, Cristina ;

Angeles Villaronga, M. ;

Casado, Pedro ;

Hermida-Prado, Francisco ;

Granda-Diaz, Rocio ;

Rodrigo, Juan P. ;

Calvo, Fernando ;

del-Rio-Ibisate, Nagore ;

Gandarillas, Alberto ;

Moris, Francisco ;

Hermsen, Mario ;

Cutillas, Pedro ;

Garcia-Pedrero, Juana M. .

CANCERS, 2018, 10 (09)

[7] VEGF in Signaling and Disease: Beyond Discovery and Development [J].

Apte, Rajendra S. ;

Chen, Daniel S. ;

Ferrara, Napoleone .

CELL, 2019, 176 (06) :1248-1264

[8] Effects of DSPP and MMP20 Silencing on Adhesion, Metastasis, Angiogenesis, and Epithelial-Mesenchymal Transition Proteins in Oral Squamous Cell Carcinoma Cells [J].

Aseervatham, Jaya ;

Ogbureke, Kalu U. E. .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (13) :1-13

[9] The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis [J].

Asif, Paris Jabeen ;

Longobardi, Ciro ;

Hahne, Michael ;

Medema, Jan Paul .

CANCERS, 2021, 13 (18)

[10] A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression [J].

Auciello, Francesca R. ;

Bulusu, Vinay ;

Oon, Chet ;

Tat-Mulder, Jacqueline ;

Berry, Mark ;

Bhattacharyya, Sohinee ;

Tumanov, Sergey ;

Allen-Petersen, Brittany L. ;

Link, Jason ;

Kendsersky, Nicholas D. ;

Vringer, Esmee ;

Schug, Michelle ;

Novo, David ;

Hwang, Rosa F. ;

Evans, Ronald M. ;

Nixon, Colin ;

Dorrell, Craig ;

Morton, Jennifer P. ;

Norman, Jim C. ;

Sears, Rosalie C. ;

Kamphorst, Jurre J. ;

Sherman, Mara H. .

CANCER DISCOVERY, 2019, 9 (05) :617-627

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