The interplay of drug therapeutics and immune responses to SARS-CoV-2

被引：5
|
作者：
Fumagalli, Valeria [1 ,2 ]
Iannacone, Matteo [1 ,2 ,3 ]
机构：
[1] IRCCS San Raffaele Sci Inst, Div Immunol Transplantat & Infect Dis, Milan, Italy
[2] Univ Vita Salute San Raffaele, Milan, Italy
[3] IRCCS San Raffaele Sci Inst, Expt Imaging Ctr, Milan, Italy
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2024年 / 21卷 / 02期
基金：
欧洲研究理事会;
关键词：
SARS-CoV-2; Nirmatrelvir; Bisphosphonates; Adaptive immunity; Drug repurposing; ZOLEDRONIC ACID; BISPHOSPHONATE THERAPY; CELLS; MECHANISMS; MONOCYTES; SAFETY;
D O I：
10.1038/s41423-023-01098-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The SARS-CoV-2 pandemic has necessitated rapid therapeutic and preventative responses. While vaccines form the frontline of defense, antiviral treatments such as nirmatrelvir have emerged as vital adjunctive measures, particularly for those unable or unwilling to be vaccinated. This review delves into the potential influence of nirmatrelvir on enduring immunity. In parallel, the potential of drug repurposing is explored, with bisphosphonates being examined for their possible effects against COVID-19 due to their immunomodulatory properties. The importance of rigorous clinical trials and careful interpretation of preliminary data is emphasized.
引用
收藏
页码：197 / 200
页数：4
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