Refining Risk for Alzheimer's Disease Among Heterozygous APOE ε4 Carriers

被引：4

作者：

Patel, Smita ^{[1
]}

Wei, Jun ^{[2
]}

Shi, Zhuqing ^{[2
]}

Rifkin, Andrew S. ^{[2
]}

Zheng, S. Lilly ^{[2
]}

Gelfman, Elizabeth ^{[3
]}

Duggan, David ^{[4
]}

Helfand, Brian T. ^{[2
,5
]}

Hulick, Peter J. ^{[6
]}

Xu, Jianfeng ^{[2
,5
]}

机构：

[1] NorthShore Univ HlthSyst, Dept Neurol, Evanston, IL USA

[2] NorthShore Univ HlthSyst, Program Personalized Canc Care, Evanston, IL USA

[3] Northwestern Feinberg Sch Med, Chicago, IL USA

[4] City Hope Natl Med Ctr, Translat Genom Res Inst, Phoenix, AZ USA

[5] Univ Chicago, Pritzker Sch Med, Chicago, IL USA

[6] NorthShore Univ HlthSyst, Neaman Ctr Personalized Med, Evanston, IL USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2023年 / 94卷 / 02期

关键词：

Alzheimer's disease; APOE; genetic counseling; polygenic risk score; UK Biobank; APOLIPOPROTEIN-E; DISCLOSURE; GENOTYPE;

D O I：

10.3233/JAD-230156

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a large population-based cohort, we show not all heterozygous APOE epsilon 4 carriers are at increased risk for Alzheimer's disease (AD); a significantly higher AD proportion was only found for epsilon 3/epsilon 4, not epsilon 2/epsilon 4. Among epsilon 3/epsilon 4 carriers (24% in the cohort), the AD proportion differed considerably by polygenic risk score (PRS). In particular, the AD proportion was lower than the entire cohort for subjects in the bottom 20-percentile PRS and was higher than that of homozygous epsilon 4 carriers for subjects at the top 5th-percentile PRS. Family history was no longer a significant predictor of AD risk after adjusting APOE and PRS.

引用

页码：483 / 489

页数：7

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