How Do You Build a Cognitive Map? The Development of Circuits and Computations for the Representation of Space in the Brain

被引:2
作者
Donato, Flavio [1 ]
Schwartzlose, Anja Xu [1 ]
Mendes, Renan Augusto Viana [1 ]
机构
[1] Univ Basel, Biozentrum, Basel, Switzerland
基金
欧洲研究理事会; 瑞士国家科学基金会;
关键词
development; cognitive map; entorhinal cortex; hippocampus; navigation; memory; HEAD-DIRECTION CELLS; HIPPOCAMPAL ENSEMBLE CODE; FREELY MOVING RATS; PATH-INTEGRATION; GRID CELLS; PLACE CELLS; SPATIAL REPRESENTATION; ATTRACTOR DYNAMICS; SYNCHRONOUS BURSTS; GEOMETRIC BORDERS;
D O I
10.1146/annurev-neuro-090922-010618
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In mammals, the activity of neurons in the entorhinal-hippocampal network is modulated by the animal's position and its movement through space. At multiple stages of this distributed circuit, distinct populations of neurons can represent a rich repertoire of navigation-related variables like the animal's location, the speed and direction of its movements, or the presence of borders and objects. Working together, spatially tuned neurons give rise to an internal representation of space, a cognitive map that supports an animal's ability to navigate the world and to encode and consolidate memories from experience. The mechanisms by which, during development, the brain acquires the ability to create an internal representation of space are just beginning to be elucidated. In this review, we examine recent work that has begun to investigate the ontogeny of circuitry, firing patterns, and computations underpinning the representation of space in the mammalian brain.
引用
收藏
页码:281 / 299
页数:19
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