Chemical constituents of the leaves of Taxus wallichiana (Taxaceae)

被引：2

作者：

Le, Thinh Duc ^{[1
,2
]}

Le, Da Vy Thi ^{[1
,2
]}

Tran, Tu Hoai ^{[1
,2
]}

Dang, Phu Hoang ^{[1
,2
]}

Le, Tho Huu ^{[1
,2
]}

Nguyen, Mai Thanh Thi ^{[1
,2
]}

Nguyen, Nhan Trung ^{[1
,2
,3
]}

机构：

[1] Univ Sci, Fac Chem, Ho Chi Minh City, Vietnam

[2] Vietnam Natl Univ Ho Chi Minh City, Management Agcy, Ho Chi Minh City, Vietnam

[3] VNUHCM Univ Sci, Fac Chem, 227 Nguyen Cu St,Ward 4,Dist 5, Ho Chi Minh City 72711, Vietnam

来源：

VIETNAM JOURNAL OF CHEMISTRY | 2024年 / 62卷 / 01期

关键词：

alpha-glucosidase inhibitory activity; Taxaceae; Taxus wallichiana; LIGNANS;

D O I：

10.1002/vjch.202300059

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From CHCl3-soluble extract of the leaves of Taxus wallichiana (Taxaceae), collected in Lam Dong Province, five compounds were isolated and identified as sciadopitysin (1), ginkgetin (2), (S)-(+)-rhododenol (3), (+)-erythro-N-benzoyl-3-phenylisoserine methyl ester (4), and (-)-alpha-conidendrin (5). Their chemical structures were determined by 1D and 2D NMR spectra and comparison with published data. Except for (-)-alpha-conidendrin, these remaining compounds were first reported of Taxus wallichiana. Among these compounds, ginkgetin (2), and (-)-alpha-conidendrin (5) showed significant alpha-glucosidase inhibitory activity with the IC50 values of 98.5, and 172.1 mu m, respectively.

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页码：37 / 42

页数：6

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