Residual pulmonary infiltrates, symptoms and diffusion impairment at 1-year after severe COVID-19 infection have different associated factors

被引：5

作者：

Menendez, Rosario ^{[1
,2
,3
,26
]}

Mendez, Raul ^{[1
,2
,3
]}

Latorre, Ana ^{[1
,2
]}

Gonzalez-Jimenez, Paula ^{[1
,2
,4
]}

Peces-Barba, German ^{[5
]}

Molina, Maria ^{[6
]}

Espana, Pedro Pablo ^{[7
]}

Garcia, Estela ^{[8
]}

Consuegra-Vanegas, Angelica ^{[9
]}

Pando-Sandoval, Ana ^{[10
]}

Panadero, Carolina ^{[11
]}

Figueira-Goncalves, Juan Marco ^{[12
]}

de la Rosa, David ^{[13
]}

Sibila, Oriol ^{[14
]}

Martinez-Pitarch, Maria Dolores ^{[15
]}

Toledo, Nuria ^{[16
]}

Cejudo, Pilar ^{[17
]}

Almonte-Batista, Wanda ^{[18
]}

Macias-Paredes, Abigail ^{[19
]}

Badenes, Diana ^{[20
]}

Perez-Rodas, Eli Nancy ^{[21
]}

Lazaro, Javier ^{[22
]}

Quiros, Sarai ^{[23
]}

Cordovilla, Rosa ^{[24
]}

Cano-Pumarega, Irene ^{[3
,25
]}

Torres, Antoni ^{[3
,14
]}

机构：

[1] Hosp Univ & Politecn La Fe, Valencia, Spain

[2] Inst Invest Sanitaria La Fe IISLAFE, Valencia, Spain

[3] Inst Salud Carlos III, CIBER Enfermedades Resp CIBERES, Madrid, Spain

[4] Univ Valencia, Valencia, Spain

[5] Hosp Fdn Jimenez Diaz, Madrid, Spain

[6] Hosp Bellvitge Princeps Espanya, Lhospitalet De Llobregat, Spain

[7] Hosp Galdakao Usansolo, Galdakao, Spain

[8] Hosp Cabuenes, Gijon, Spain

[9] Hosp Univ A Coruna, La Coruna, Spain

[10] Hosp Univ Cent Asturias, Oviedo, Spain

[11] Hosp Getafe, Getafe, Spain

[12] Hosp Nuestra Senora Candelaria, Santa Cruz De Tenerife, Spain

[13] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[14] Hosp Clin Barcelona, Barcelona, Spain

[15] Hosp Lluis Alcanyis, Jativa, Spain

[16] Hosp Son Espases, Palma De Mallorca, Spain

[17] Hosp Virgen Rocio, Seville, Spain

[18] Hosp Albacete, Albacete, Spain

[19] Hosp St Jaume, Calella, Spain

[20] Hosp Mar, Barcelona, Spain

[21] Hosp Mayo, Barcelona, Spain

[22] Hosp Royo Villanova, Zaragoza, Spain

[23] Hosp Basurto, Bilbao, Spain

[24] Hosp Univ Salamanca, Salamanca, Spain

[25] Hosp Univ Ramon & Cajal, IRYCIS, Madrid, Spain

[26] Hosp Univ & Politecn La Fe, Pneumol Dept, Avda Fernando Abril Martorell 106, Valencia 46026, Spain

来源：

JOURNAL OF INTERNAL MEDICINE | 2023年 / 294卷 / 01期

关键词：

COVID-19; RECOVID; SARS-CoV-2; SEPAR; CONSEQUENCES;

D O I：

10.1111/joim.13642

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Menendez R, Mendez R, Latorre A, Gonzalez-Jimenez P, Peces-Barba G, Molina M, et al. Residual pulmonary infiltrates, symptoms and diffusion impairment at 1-year after severe COVID-19 infection have different associated factors. J Intern Med. 2023;00:1-13. Introduction. After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1-year followup. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (DLCO) at 1-year follow-up in patients from the Spanish Registry RECOVID. Methods. RECOVID collected symptom and radiological and functional lung tests data on hospitalized patients with coronavirus disease 2019 during the acute phase and at the 6- and 12-month follow-up visits. Results. Of the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow-up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae and 31% had reduced DLCO. Independently associated factors included female sex, asthma and the requirement for invasive or non-invasive mechanical ventilation. Complete radiological resolution was 72.2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO(2)/FiO(2) <450 or CURB-65 >= 2. Reduced D-LCO was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO(2)/FiO(2) <450 and CURB-65 >= 2 and the requirement of respiratory support.At 12 months, a proportion of the asymptomatic patients showed reduced D-LCO (9.5%), radiological findings (25%) or both (11%). Conclusions. The factors associated with symptom persistence, incomplete radiological resolution and D-LCO <80% differed according to age, sex, comorbidities and respiratory support. The burden of symptoms, reduced D-LCO and incomplete radiological resolution were considerable in patients with SARS-CoV-2 pneumonia at the 1-year follow-up after hospitalisation.

引用

页码：69 / 82

页数：14

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