Microbiome and Human Health: Current Understanding, Engineering, and Enabling Technologies

被引：191

作者：

Aggarwal, Nikhil ^{[1
]}

Kitano, Shohei ^{[1
]}

Puah, Ginette Ru Ying ^{[1
,2
,3
]}

Kittelmann, Sandra ^{[2
,3
]}

Hwang, In Young ^{[1
,4
,5
]}

Chang, Matthew Wook ^{[1
,2
,4
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, NUS Synthet Biol Clin & Technol Innovat SynCTI & S, Singapore 117456, Singapore

[2] Natl Univ Singapore, Wilmar NUS WIL NUS Corp Lab, Singapore 117599, Singapore

[3] Wilmar Int Ltd, Singapore 138568, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117596, Singapore

[5] Singapore Inst Technol, Singapore 138683, Singapore

来源：

CHEMICAL REVIEWS | 2023年 / 123卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

IRRITABLE-BOWEL-SYNDROME; LOWER BIFIDOBACTERIA COUNTS; GENOME-WIDE ASSOCIATION; GUT MICROBIOTA; FECAL MICROBIOTA; INTESTINAL MICROBIOTA; STAPHYLOCOCCUS-AUREUS; BACTERIAL COMMUNITIES; PROPIONIBACTERIUM-ACNES; ESCHERICHIA-COLI;

D O I：

10.1021/acs.chemrev.2c00431

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The human microbiome is composed of a collection of dynamic microbial communities that inhabit various anatomical locations in the body. Accordingly, the coevolution of the microbiome with the host has resulted in these communities playing a profound role in promoting human health. Consequently, perturbations in the human microbiome can cause or exacerbate several diseases. In this Review, we present our current understanding of the relationship between human health and disease development, focusing on the microbiomes found across the digestive, respiratory, urinary, and reproductive systems as well as the skin. We further discuss various strategies by which the composition and function of the human microbiome can be modulated to exert a therapeutic effect on the host. Finally, we examine technologies such as multiomics approaches and cellular reprogramming of microbes that can enable significant advancements in microbiome research and engineering.

引用

页码：31 / 72

页数：42

共 475 条

[1] Defining the normal bacterial flora of the oral cavity [J].