Thrombolysis in Patients With Large-Vessel Occlusion Directly Admitted or Transferred to a Thrombectomy Center: A Population-Based Study

被引：1

作者：

Garcia-Tornel, Alvaro ^{[1
]}

Lozano, Prudencio ^{[1
]}

Rubiera, Marta ^{[1
]}

Requena, Manuel ^{[1
]}

Olive-Gadea, Marta ^{[1
]}

Muchada, Marian ^{[1
]}

Juega, Jesus ^{[1
]}

Rizzo, Federica ^{[1
]}

Rodriguez-Villatoro, Noelia ^{[1
]}

Pagola, Jorge ^{[1
]}

Rodriguez-Luna, David ^{[1
]}

Boned, Sandra ^{[1
]}

Dorado, Laura ^{[2
]}

Jimenez, Xavier ^{[3
]}

Soto, Angels ^{[3
]}

Cardona, Pere ^{[4
]}

Urra, Xabier ^{[5
,8
]}

Chamorro, Angel ^{[5
]}

Purroy, Francesc ^{[6
]}

Terceno, Mikel ^{[7
]}

Silva, Yolanda ^{[7
]}

Flores, Alan ^{[8
]}

Ustrell, Xavier

Zaragoza, Josep ^{[9
]}

Roquer, Jaume ^{[10
]}

Kuprinski, Jerzy ^{[11
]}

Cocho, Dolores ^{[12
]}

Palomeras, Ernest ^{[13
]}

Gomez-Choco, Manuel ^{[14
]}

Canovas, David ^{[15
]}

Marti-Fabregas, Joan ^{[16
]}

Mas, Natalia ^{[17
]}

Abilleira, Sonia ^{[18
]}

Molina, Carlos ^{[1
]}

Ribo, Marc ^{[1
]}

Perez de la Ossa, Natalia ^{[2
,19
]}

机构：

[1] Hosp Univ Vall dHebron, Dept Neurol, Stroke Unit, Psg Vall dHebron 119-129, Barcelona 08035, Spain

[2] Hosp Badalona Germans Trias & Pujol, Dept Neurol, Badalona, Spain

[3] Emergency Med Serv Catalonia, Barcelona, Spain

[4] Hosp Univ Bellvitge, Stroke Unit, Dept Neurol, Barcelona, Spain

[5] Hosp Clin Barcelona, Stroke Unit, Dept Neurol, Barcelona, Spain

[6] Hosp Arnau Vilanova Lleida, UdL, Dept Neurol, IRBLleida,Stroke Unit, Lleida, Spain

[7] Hosp Josep Trueta, Stroke Unit, Dept Neurol, Girona, Spain

[8] Hosp Joan 23, Stroke Unit, Dept Neurol, Tarragona, Spain

[9] Hosp Verge Cinta, Stroke Unit, Dept Neurol, Tortosa, Spain

[10] Hosp del Mar, Stroke Unit, Dept Neurol, Barcelona, Spain

[11] Hosp Univ Mutua Terrassa, Dept Neurol, Terrassa, Spain

[12] Hosp Granollers, Dept Neurol, Barcelona, Spain

[13] Hosp Mataro, Dept Neurol, Mataro, Spain

[14] Complex Hosp Moises Broggi, Dept Neurol, Sant Joan Despi, Spain

[15] Hosp Parc Tauli, Dept Neurol, Sabadell, Spain

[16] Hosp Santa Creu & Sant Pau, Stroke Unit, Dept Neurol, Barcelona, Spain

[17] Hosp St Joan Deu Fundacio Althaia, Dept Neurol, Manresa, Spain

[18] Catalan Hlth Inst ICS, Barcelona, Spain

[19] Agcy Hlth Qual & Assessment Catalonia, Catalan Hlth Dept, Stroke Programme, Barcelona, Spain

来源：

STROKE-VASCULAR AND INTERVENTIONAL NEUROLOGY | 2023年 / 3卷 / 05期

关键词：

acute stroke; emergency medical services; nonurban areas; thrombectomy; thrombolysis; ACUTE ISCHEMIC-STROKE; ENDOVASCULAR TREATMENT; INTRAVENOUS THROMBOLYSIS; MECHANICAL THROMBECTOMY; ALTEPLASE; RECANALIZATION; ASSOCIATION; REPERFUSION; OUTCOMES; TRIAL;

D O I：

10.1161/SVIN.122.000760

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BACKGROUND: Our goal is to evaluate whether the administration of thrombolytic treatment has varying effects on clinical and radiological outcomes in patients with large-vessel occlusion stroke, based on the type of stroke center where the treatment was given (thrombectomy-capable center versus local stroke center). METHODS: We included patients with an acute ischemic large-vessel occlusion stroke who were directly admitted to thrombectomy-capable centers and treated with endovascular thrombectomy, or were transferred from local stroke centers as thrombectomy candidates, in Catalonia, Spain, between 2017 and 2021. The primary outcome was the shift analysis on the modified Rankin scale score at 90 days. Secondary outcomes included death at 90 days and the rate of parenchymal hemorrhage and successful reperfusion. Inverse-probability weighting clustered at the type of stroke center was used to estimate the effects. RESULTS: The analysis included 2268 patients directly admitted to thrombectomy-capable centers, of whom 975 (49%) were treated with thrombolysis, and 938 patients transferred from local stroke centers, of whom 580 (66%) were treated with thrombolysis and 616 (67%) were treated with thrombectomy. Mean age was 72 (SD +/- 13) years, median National Institute of Health Stroke Scale score was 17 (interquartile range, 12-21), and 1363 patients were women (48%). Patients treated with intravenous thrombolysis were younger, had shorter time from onset to first image, higher Alberta Stroke Program Early Computed Tomography Score, and lower rates of wake-up stroke, atrial fibrillation, and anticoagulation intake. Patients treated with thrombolysis had better functional outcome at 90 days, with no difference between patients directly admitted to thrombectomy-capable centers (adjusted common odds ratio [acOR], 1.50 [95% CI, 1.24-1.81]) and patients transferred from local stroke centers (acOR, 1.44 [95% CI, 1.04-2.01]). Patients treated with intravenous thrombolysis had lower death rate, higher rate of parenchymal hematoma, and similar rate of successful reperfusion, with no difference according to type of center (Pinteraction>0.1). CONCLUSION: Administration of intravenous thrombolysis in patients with a large-vessel stroke with intention of thrombectomy was associated with lower degrees of disability, lower death rate, and higher rates of parenchymal hematoma both in thrombectomycapable centers and in local stroke centers.

引用

页数：10

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