Adjunctive antidepressants for the treatment of bipolar depression: An updated meta-analysis of randomized clinical trials

被引：4

作者：

Shafiee, Arman ^{[1
,2
,5
]}

Moltazemi, Hassan ^{[3
]}

Amini, Mohammad Javad ^{[2
]}

Gargari, Omid Kohandel ^{[2
]}

Safari, Farima ^{[4
]}

Abhari, Faeze Soltani ^{[1
]}

Jafarabady, Kyana ^{[1
]}

Bakhtiyari, Mahmood ^{[1
,5
]}

机构：

[1] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran

[2] Alborz Univ Med Sci, Student Res Comm, Sch Med, Karaj, Iran

[3] Univ Tehran Med Sci, Student Res Comm, Sch Med, Tehran, Iran

[4] Shiraz Univ Med Sci, Student Res Comm, Sch Med, Shiraz, Iran

[5] Alborz Univ Med Sci, Karaj, Alborz Province, Iran

来源：

ASIAN JOURNAL OF PSYCHIATRY | 2024年 / 91卷

关键词：

Antidepressants; Bipolar disorder; Bipolar depression; DOUBLE-BLIND; MOOD STABILIZER; COMBINATION; LAMOTRIGINE; THERAPY; PLACEBO; OLANZAPINE; FLUOXETINE; PAROXETINE; EFFICACY;

D O I：

10.1016/j.ajp.2023.103839

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This updated meta-analysis aims to evaluate the efficacy of adjunctive antidepressants in the treatment of bipolar depression. The antidepressant group exhibited a significant increase in response rate (RR: 1.12; 95 % CI 1.01-1.25; p = 0.04; I2 = 55 %). The pooled results demonstrated a significant increase in response rate in the antidepressant group (RR: 1.12 95 % CI 1.01-1.25, p = 0.04; I2 = 55 %). Depression score was significantly lower in the antidepressant group (SMD:-0.20 95 % CI-0.31 to-0.09, p < 0.001; I2 = 14 %). Egger's regression test and funnel plot inspection did not suggest publication bias. Adjunctive antidepressants appear to enhance response rates and reduce depressive scores in bipolar depression, though potential biases and study heterogeneity warrant future randomized trials on this topic.

引用

页数：6

共 34 条

[1] Switch Rates During Acute Treatment for Bipolar II Depression With Lithium, Sertraline, or the Two Combined: A Randomized Double-Blind Comparison [J].

Altshuler, Lori L. ;

Sugar, Catherine A. ;

McElroy, Susan L. ;

Calimlim, Brian ;

Gitlin, Michael ;

Keck, Paul E., Jr. ;

Aquino-Elias, Ana ;

Martens, Brian E. ;

Fischer, Grace ;

English, Teri L. ;

Roach, Janine ;

Suppes, Trisha .

AMERICAN JOURNAL OF PSYCHIATRY, 2017, 174 (03) :266-276

[2] Comparison of fluoxetine, olanzapine, and combined fluoxetine plus olanzapine initial therapy of bipolar type I and type II major depression - lack of manic induction [J].

Amsterdam, JD ;

Shults, J .

JOURNAL OF AFFECTIVE DISORDERS, 2005, 87 (01) :121-130

[3] Bipolar depression: a major unsolved challenge [J].

Baldessarini, Ross J. ;

Vazquez, Gustavo H. ;

Tondo, Leonardo .

INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS, 2020, 8 (01)

[4] A 7-week, randomized, double-blind trial of olanzapine/fluoxetine combination versus lamotrigine in the treatment of bipolar I depression [J].

Brown, Eileen B. ;

McElroy, Susan L. ;

Keck, Paul E., Jr. ;

Deldar, Ahmed ;

Adams, David H. ;

Tohen, Mauricio ;

Williamson, Douglas J. .

JOURNAL OF CLINICAL PSYCHIATRY, 2006, 67 (07) :1025-1033

[5]

Chen Q., 2017, Chin. J. Prim. Med. Pharmacol., V24, P1250

[6] Long-term morbidity in bipolar-I, bipolar-II, and unipolar major depressive disorders [J].

Forte, Alberto ;

Saldessarini, Ross J. ;

Tondo, Leonardo ;

Vazquez, Gustavo H. ;

Pompili, Maurizio ;

Girardi, Paolo .

JOURNAL OF AFFECTIVE DISORDERS, 2015, 178 :71-78

[7] Citalopram for Acute and Preventive Efficacy in Bipolar Depression (CAPE-BD): A Randomized, Double-Blind, Placebo-Controlled Trial [J].

Ghaemi, S. Nassir ;

Whitham, Elizabeth A. ;

Vohringer, Paul A. ;

Barroilhet, Sergio A. ;

Amerio, Andrea ;

Sverdlov, Oleksandr ;

Patkar, Ashwin A. .

JOURNAL OF CLINICAL PSYCHIATRY, 2021, 82 (01)

[8] Antidepressant Discontinuation in Bipolar Depression: A Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) Randomized Clinical Trial of Long-Term Effectiveness and Safety [J].

Ghaemi, S. Nassir ;

Ostacher, Michael M. ;

El-Mallakh, Rif S. ;

Borrelli, David ;

Baldassano, Claudia F. ;

Kelley, Mary E. ;

Filkowski, Megan M. ;

Hennen, John ;

Sachs, Gary S. ;

Goodwin, Frederick K. ;

Baldessarini, Ross J. .

JOURNAL OF CLINICAL PSYCHIATRY, 2010, 71 (04) :372-380

[9] Adjunctive antidepressants for the acute treatment of bipolar depression: A systematic review and meta-analysis [J].

Hu, Yuliang ;

Zhang, Huijuan ;

Wang, Hongyan ;

Wang, Chris ;

Kung, Simon ;

Li, Chunbo .

PSYCHIATRY RESEARCH, 2022, 311

[10] Psychosocial disability and work role function compared across the long-term course of bipolar I, bipolar II and unipolar major depressive disorders [J].

Judd, Lewis L. ;

Schettler, Pamela J. ;

Solomon, David A. ;

Maser, Jack D. ;

Coryell, William ;

Endicott, Jean ;

Akiskal, Hagop S. .

JOURNAL OF AFFECTIVE DISORDERS, 2008, 108 (1-2) :49-58

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