Calcium and vitamin D homoeostasis in male fertility

被引:10
作者
Yahyavi, Sam Kafai [1 ,2 ]
Boisen, Ida Marie [1 ,2 ]
Cui, Zhihui [1 ,2 ]
Jorsal, Mads Joon [1 ,2 ]
Kooij, Ireen [1 ,2 ]
Holt, Rune [1 ,2 ]
Juul, Anders [3 ,4 ,5 ]
Jensen, Martin Blomberg [1 ,2 ]
机构
[1] Copenhagen Univ Hosp Herlev & Gentofte, Dept Endocrinol & Internal Med, Div Translat Endocrinol, Herlev, Denmark
[2] Copenhagen Univ Hosp, Rigshosp, Grp Skeletal Mineral & Gonadal Endocrinol, Rigshospitalet, Copenhagen, Denmark
[3] Copenhagen Univ Hosp, Rigshosp, Rigshospitalet, Copenhagen, Denmark
[4] Copenhagen Univ Hosp, Rigshosp, Rigshospitalet, Copenhagen, Denmark
[5] Copenhagen Univ Hosp, Rigshosp, Dept Clin Med, Copenhagen, Denmark
关键词
Vitamin D; Calcium; Fertility; Male reproduction; SENSING RECEPTOR CASR; IONIZED CALCIUM; SPERM MOTILITY; D DEFICIENCY; SEMINAL PLASMA; 1-ALPHA; 25(OH)(2); VITAMIN-D-3; CA2+-SENSING RECEPTOR; EXTRACELLULAR CALCIUM; SEMINIFEROUS TUBULES; INTRALUMINAL FLUIDS;
D O I
10.1017/S002966512300486X
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Calcium and vitamin D have well-established roles in maintaining calcium balance and bone health. Decades of research in human subjects and animals have revealed that calcium and vitamin D also have effects on many other organs including male reproductive organs. The presence of calcium-sensing receptor, vitamin D receptor, vitamin D activating and inactivating enzymes and calcium channels in the testes, male reproductive tract and human spermatozoa suggests that vitamin D and calcium may modify male reproductive function. Functional animal models have shown that vitamin D deficiency in male rodents leads to a decrease in successful mating and fewer pregnancies, often caused by impaired sperm motility and poor sperm morphology. Human studies have to a lesser extent validated these findings; however, newer studies suggest a positive effect of vitamin D supplementation on semen quality in cases with vitamin D deficiency, which highlights the need for initiatives to prevent vitamin D deficiency. Calcium channels in male reproductive organs and spermatozoa contribute to the regulation of sperm motility and capacitation, both essential for successful fertilisation, which supports a need to avoid calcium deficiency. Studies have demonstrated that vitamin D, as a regulator of calcium homoeostasis, influences calcium influx in the testis and spermatozoa. Emerging evidence suggests a potential link between vitamin D deficiency and male infertility, although further investigation is needed to establish a definitive causal relationship. Understanding the interplay between vitamin D, calcium and male reproductive health may open new avenues for improving fertility outcomes in men.
引用
收藏
页码:95 / 108
页数:14
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