Design, Synthesis, Biological Evaluation and Molecular Docking Studies of Quercetin-Linker-H2S Donor Conjugates for the Treatment of Diabetes and Wound Healing

Based on the use of quercetin for treating diabetes and H2S for promoting wound healing, a series of three quercetin-linker-H2S donor conjugates was designed, synthesized and characterized by H-1-NMR, C-13-NMR and MS. Meanwhile, in vitro evaluation of these compounds was also researched by IR-HepG2 treatment experiment, MTT assay, scratch test and tubule formation experiment. The three compounds could be used to treat insulin resistance induced by high glucose and promote the proliferation of human umbilical vein endothelial cells, wound healing, and the formation of tubules in vitro under a high-glucose environment. Our results illustrate that these compounds could be used to treat diabetes and promote wound healing at the same time. Furthermore, molecular docking study results of the compounds were consistent with the evaluated biological activity. In vivo research of compounds is underway.