Gut microbes involvement in gastrointestinal cancers through redox regulation

被引:1
作者
Yangyanqiu, Wang [1 ,2 ,4 ]
Jian, Chu [1 ,3 ,4 ]
Yuqing, Yang [1 ,4 ]
Zhanbo, Qu [1 ,3 ,4 ]
Shuwen, Han [1 ,4 ]
机构
[1] Huzhou Univ, Huzhou Cent Hosp, Affiliated Cent Hosp, 1558 Sanhuan North Rd, Huzhou 313000, Zhejiang, Peoples R China
[2] Zhejiang Univ, Med Coll, Grad Sch, 268 Kaixuan Rd, Hangzhou 310029, Zhejiang, Peoples R China
[3] Zhejiang Chinese Med Univ, 548 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China
[4] Key Lab Multi Res & Clin Transformat Digest Canc, 1558 Sanhuan North Rd, Huzhou 313000, Zhejiang, Peoples R China
关键词
Gastrointestinal microbes; Gastrointestinal cancers; Redox; Reactive oxygen species; Oxidative stress; REACTIVE OXYGEN; NITRIC-OXIDE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; DRUG-RESISTANCE; PYRUVATE-DEHYDROGENASE; DEPENDENT REGULATION; MAJOR MICROBIOTA; GASTRIC-CANCER; ROS;
D O I
10.1186/s13099-023-00562-z
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Gastrointestinal (GI) cancers are among the most common and lethal cancers worldwide. GI microbes play an important role in the occurrence and development of GI cancers. The common mechanisms by which GI microbes may lead to the occurrence and development of cancer include the instability of the microbial internal environment, secretion of cancer-related metabolites, and destabilization of the GI mucosal barrier. In recent years, many studies have found that the relationship between GI microbes and the development of cancer is closely associated with the GI redox level. Redox instability associated with GI microbes may induce oxidative stress, DNA damage, cumulative gene mutation, protein dysfunction and abnormal lipid metabolism in GI cells. Redox-related metabolites of GI microbes, such as short-chain fatty acids, hydrogen sulfide and nitric oxide, which are involved in cancer, may also influence GI redox levels. This paper reviews the redox reactions of GI cells regulated by microorganisms and their metabolites, as well as redox reactions in the cancer-related GI microbes themselves. This study provides a new perspective for the prevention and treatment of GI cancers.
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页数:10
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