New Indole Diketopiperazine Alkaloids from Soft Coral-Associated Epiphytic Fungus Aspergillus versicolor CGF 9-1-2

被引：8

作者：

Hu, Jin-Shan ^{[1
,2
]}

He, Yu-Pei ^{[1
]}

Zhou, Feng-Guo ^{[1
]}

Wu, Ping-Ping ^{[1
]}

Chen, Le-Yi ^{[1
]}

Ni, Cheng ^{[1
]}

Zhang, Ze-Kun ^{[1
]}

Xiao, Xi-Ji ^{[1
]}

An, Lin-Kun ^{[3
]}

He, Xi-Xin ^{[1
]}

Zhang, Cui-Xian ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[2] First Compulsory Isolated Detoxificat Ctr Shenzhen, Municipal Bur Justice, Shenzhen 518024, Peoples R China

[3] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2023年 / 20卷 / 06期

基金：

中国国家自然科学基金;

关键词：

A; versicolor CGF 9-1-2; IDAs; inhibitory effect; molecular docking; soft coral-associated epiphytic fungus; MARINE; BIOSYNTHESIS; TDP1;

D O I：

10.1002/cbdv.202300301

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new indole diketopiperazine alkaloids (IDAs), (+)19-epi-sclerotiamide (1) and (-)19-epi-sclerotiamide (2), along with 13 known analogs (3-15), were isolated from a soft coral-associated epiphytic fungus Aspergillus versicolor CGF 9-1-2. The structures of two new compounds were established based on the combination of HR-ESI-MS, 1D and 2D NMR spectroscopy, optical rotation measurements and quantum chemical C-13-NMR, the absolute configurations were determined by experimental and electronic circular dichroism (ECD) calculations. The results of molecular docking showed that all the compounds had a good binding with TDP1, TDP2, TOP1, TOP2, Ache, NLRP3, EGFR, EGFR L858R, EGFR T790M and EGFR T790/L858. Biological evaluation of compounds 3, 6, 8, 11 showed that 3 exerted a strong inhibitory effect on TDP2 with a rate of 81.72 %.

引用

页数：8

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