Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT)

被引：56

作者：

Mohty, Mohamad ^{[1
,2
]}

Malard, Florent ^{[1
,2
]}

Alaskar, Ahmed S. ^{[3
]}

Aljurf, Mahmoud ^{[4
]}

Arat, Mutlu ^{[5
]}

Bader, Peter ^{[6
]}

Baron, Frederic ^{[7
]}

Bazarbachi, Ali ^{[8
]}

Blaise, Didier ^{[9
]}

Brissot, Eolia ^{[1
,2
]}

Ciceri, Fabio ^{[10
]}

Corbacioglu, Selim ^{[11
]}

Dalle, Jean-Hugues ^{[12
]}

Dignan, Fiona ^{[13
]}

Huynh, Anne ^{[14
]}

Kenyon, Michelle ^{[15
]}

Nagler, Arnon ^{[16
]}

Pagliuca, Antonio ^{[15
]}

Peric, Zinaida ^{[17
,18
]}

Richardson, Paul G. ^{[19
]}

Ruggeri, Annalisa ^{[10
]}

Ruutu, Tapani ^{[20
]}

Yakoub-Agha, Ibrahim ^{[21
]}

Duarte, Rafael F. ^{[22
]}

Carreras, Enric ^{[23
,24
]}

机构：

[1] Hop St Antoine, Hematol Dept, Paris, France

[2] Univ Paris 06, Paris, France

[3] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Dept Oncol, King Abdulaziz Med City,Minist Natl Guard Hlth Aff, Riyadh, Saudi Arabia

[4] King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia

[5] Sisli Florence Nightingale Hosp, HSCT Unit, Istanbul, Turkiye

[6] Goethe Univ, Univ Hosp, Dept Children & Adolescents, Div Stem Cell Transplantat & Immunol, Frankfurt, Germany

[7] Univ Liege, Dept Hematol, Liege, Belgium

[8] Amer Univ Beirut, Dept Internal Med, Beirut, Lebanon

[9] Aix Marseille Univ, Inst Paoli Calmettes, Dept Hematol, MSC Lab, Marseille, France

[10] Ist Sci San Raffaele, Hematol & Bone Marrow Transplantat Unit, Milan, Italy

[11] Univ Regensburg, Dept Pediat Hematol Oncol & Stem Cell Transplantat, Regensburg, Germany

[12] Paris 7 Paris Diderot Univ, Hosp Robert Debre, Dept Hematol & Immunol, Paris, France

[13] Manchester Univ NHS Fdn Trust, Dept Clin Haematol, Manchester, England

[14] Inst Univ Canc Toulouse Oncopole, Hematol Dept, Toulouse, France

[15] Kings Coll Hosp London, Dept Haematol, London, England

[16] Chaim Sheba Med Ctr, Hematol & Bone Marrow Transplantat, Tel Hashomer, Israel

[17] Univ Zagreb, Univ Hosp Ctr Zagreb, Dept Hematol, Zagreb, Croatia

[18] Univ Zagreb, Sch Med, Zagreb, Croatia

[19] Mayo Clin, Div Hematol, Rochester, MN USA

[20] Helsinki Univ Hosp, Clin Res Inst, Helsinki, Finland

[21] Univ Lille, CHU Lille, INSERM U1286, Infinite, F-59000 Lille, France

[22] Hosp Univ Puerta de Hierro Majadahonda, Dept Hematol, Madrid, Spain

[23] Hosp Clin Barcelona, Josep Carreras Fdn, Barcelona Univ Campus, Barcelona, Spain

[24] Hosp Clin Barcelona, Leukemia Res Inst, Barcelona Univ Campus, Barcelona, Spain

来源：

BONE MARROW TRANSPLANTATION | 2023年 / 58卷 / 07期

关键词：

HEPATIC VENOOCCLUSIVE DISEASE; STEM-CELL TRANSPLANTATION; ORGAN FAILURE; LIVER; COMPLICATIONS; SEPSIS; COHORT;

D O I：

10.1038/s41409-023-01992-8

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). A new definition for diagnosis, and a severity grading system for SOS/VOD in adult patients, was reported a few years ago on behalf of the European Society for Blood and Marrow Transplantation (EBMT). The aim of this work is to update knowledge regarding diagnosis and severity assessment of SOS/VOD in adult patients, and also its pathophysiology and treatment. In particular, we now propose to refine the previous classification and distinguish probable, clinical and proven SOS/VOD at diagnosis. We also provide an accurate definition of multiorgan dysfunction (MOD) for SOS/VOD severity grading based on Sequential Organ Failure Assessment (SOFA) score.

引用

页码：749 / 754

页数：6

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