Recent advances of drugs monitoring in oral fluid and comparison with blood

被引：14

作者：

Casati, Sara ^{[2
]}

Binda, Maddalena ^{[3
]}

Dongiovanni, Paola ^{[1
]}

Meroni, Marica ^{[4
]}

D'Amato, Alfonsina ^{[3
]}

Roda, Gabriella ^{[3
]}

Orioli, Marica ^{[2
]}

Del Fabbro, Massimo ^{[2
,5
]}

Tartaglia, Gianluca M. M. ^{[2
,5
]}

机构：

[1] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Med & Metab Dis, Via F Sforza 35, I-20122 Milan, Italy

[2] Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy

[3] Univ Milan, Dept Pharmaceut Sci, Milan, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Med & Metab Dis, Milan, Italy

[5] Osped Maggiore Policlin, UOC Maxillo Facial Surg & Dent Fdn IRCCS Ca Granda, Milan, Italy

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2023年 / 61卷 / 11期

关键词：

alternative matrix; blood; drugs of abuse; drugs testing; saliva; CHROMATOGRAPHY-MASS SPECTROMETRY; AMPHETAMINE-TYPE STIMULANTS; PLASMA; SALIVA; DELTA(9)-TETRAHYDROCANNABINOL; CANNABIS; URINE; COLLECTION; PHARMACOKINETICS; SERUM;

D O I：

10.1515/cclm-2023-0343

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The use of alternative matrices in toxicological analyses has been on the rise in clinical and forensic settings. Oral fluid (OF), as non-invasive fluid, has attracted attention in the field of drug screening, both for therapeutic and forensic purposes, as well as for medical diagnosis, clinical management, on-site (real time) doping and for monitoring environmental exposure to toxic substances. A good correlation between OF and blood is now established for drug concentrations. Therefore, OF might be a potential substitute of blood, especially for long-term surveillance (e.g., therapeutic drugs) or to screen a large number of patients, as well as for the development of salivary point-of-care technologies. In this review, we aimed to summarize and critically evaluate the current literature that focused on the comparison of drugs detection in OF and blood specimens.

引用

页码：1978 / 1993

页数：16

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