Comprehensive analyses of intraoral spindle cell carcinoma: A rare disease entity revisited

被引:1
作者
Sang, Lei [1 ]
Dai, Yibin [2 ]
Hu, Jiaan [3 ]
Zhu, Yaqing [1 ]
Xu, Linhong [1 ]
Zhang, Wei [4 ]
Cheng, Jie [1 ,2 ,5 ]
机构
[1] Suzhou Huaxia Stomatol Hosp, Dept Oral & Maxillofacial Surg, Suzhou, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, Nanjing, Peoples R China
[3] Zhejiang Chinese Med Univ, Dept Stomatol, Affiliated Hosp 1, Hangzhou, Zhejiang, Peoples R China
[4] Nanjing Med Univ, Affiliated Stomatol Hosp, Dept Oral Pathol, Nanjing, Peoples R China
[5] Nanjing Med Univ, Affiliated Stomatol Hosp, Dept Oral & Maxillofacial Surg, 136 Hanzhong Rd, Nanjing 210029, Peoples R China
关键词
carcinosarcoma; Intraoral spindle cell carcinoma; sarcomatoid carcinoma; SARCOMATOID CARCINOMA; SQUAMOUS CARCINOMA; MAXILLARY SINUS; ORAL-CAVITY; CARCINOSARCOMA; HEAD; NECK; LARYNX; OUTCOMES; GINGIVA;
D O I
10.1111/odi.14037
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
ObjectiveThe present study was aimed to comprehensively characterize the epidemiological, clinicopathological characteristics, treatments, and prognosis of intraoral spindle cell carcinoma (SpCC). Materials and MethodsPatients diagnosed with intraoral SpCC at our institution in the past 15 years (2005-2019) were screened from inpatient disease registry. All relevant data concerning patients with intraoral SpCC were retrieved. Previous reports about intraoral SpCC with adequate clinicopathological data in both English literature and Chinese literature were collected. Eligible cases were further reviewed and pooled for statistical analyses. ResultsSix patients (5 females and 1 male; average age: 59 years) with intraoral SpCC were histopathologically diagnosed and surgically treated at our institution. The literature review identified another 63 published cases from 34 articles. Most cases were presented in the fifth to seventh decade of life with a male preponderance. Gingiva (23/69, 33.3%) was the most common site followed by the tongue (19/69, 27.5%) and buccal mucosa (8/69, 11.6%). Complete surgical ablation remains the primary treatment option. Tumor size, pathological grades, cervical node metastasis, and distant metastasis were significantly associated with reduced survival. ConclusionsIntraoral SpCC is an uncommon and aggressive malignancy with dismal prognosis. Much attention and effort are needed to characterize this rare entity and improve its clinical outcomes.
引用
收藏
页码:686 / 695
页数:10
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