Second TURB, restaging TURB or repeat TURB in primary T1 non-muscle invasive bladder cancer: impact on prognosis?

被引：4

作者：

Beijert, Irene J. ^{[1
,2
]}

Hentschel, Anouk E. ^{[1
,2
]}

Bruendl, Johannes ^{[3
]}

Comperat, Eva M. ^{[4
,5
]}

Plass, Karin ^{[6
]}

Rodriguez, Oscar ^{[7
]}

Henriquez, Jose D. Subiela ^{[7
]}

Hernandez, Virginia ^{[4
,8
]}

de la Pena, Enrique ^{[8
]}

Alemany, Isabel ^{[9
]}

Turturica, Diana ^{[10
]}

Pisano, Francesca ^{[7
,10
]}

Soria, Francesco ^{[10
]}

Capoun, Otakar ^{[4
,11
,12
]}

Bauerova, Lenka ^{[13
,14
]}

Pesl, Michael ^{[11
,12
]}

Bruins, H. Maxim ^{[4
,15
,16
]}

Runneboom, Willemien ^{[17
]}

Herdegen, Sonja ^{[3
]}

Breyer, Johannes ^{[3
]}

Brisuda, Antonin ^{[18
,19
]}

Calatrava, Ana ^{[20
]}

Rubio-Briones, Jose ^{[21
]}

Seles, Maximilian ^{[22
]}

Mannweiler, Sebastian ^{[23
]}

Bosschieter, Judith ^{[2
]}

Kusuma, Venkata R. M. ^{[24
]}

Ashabere, David ^{[24
]}

Huebner, Nicolai ^{[25
]}

Cotte, Juliette ^{[26
]}

Contieri, Roberto ^{[1
]}

Mertens, Laura S. ^{[1
]}

Claps, Francesco ^{[1
]}

Masson-Lecomte, Alexandra ^{[4
]}

Liedberg, Fredrik ^{[4
]}

Cohen, Daniel ^{[4
,27
]}

Lunelli, Luca ^{[28
]}

Cussenot, Olivier ^{[28
]}

El Sheikh, Soha ^{[29
]}

Volanis, Dimitrios ^{[27
]}

Cote, Jean-Francois ^{[30
]}

Roupret, Morgan ^{[4
,26
]}

Haitel, Andrea ^{[31
]}

Shariat, Shahrokh F. ^{[4
,18
,19
,25
]}

Mostafid, A. Hugh ^{[4
,24
]}

Nieuwenhuijzen, Jakko A. ^{[2
]}

Zigeuner, Richard ^{[4
,22
]}

Dominguez-Escrig, Jose L. ^{[4
,21
]}

Hacek, Jaromir ^{[32
,33
]}

Zlotta, Alexandre R. ^{[34
]}

机构：

[1] Antoni Van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Surg Oncol Urol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

[2] Vrije Univ, Amsterdam Univ Med Ctr, Urol, Amsterdam, Netherlands

[3] Univ Regensburg, Caritas St Josef Med Ctr, Urol, Regensburg, Germany

[4] European Assoc Urol, Nonmuscle Invas Bladder Canc Guidelines Panel, Arnhem, Netherlands

[5] Sorbonne Univ, Tenon Hosp, AP HP, Pathol, Paris, France

[6] European Assoc Urol, Guidelines Off Board, Arnhem, Netherlands

[7] Univ Autonoma Barcelona, Urol, Fundacio Puigvert, Barcelona, Spain

[8] Hosp Univ Fdn Alcorcon, Urol, Madrid, Spain

[9] Hosp Univ Fdn Alcorcon, Pathol, Madrid, Spain

[10] Univ Torino, Citta Salute & Sci, Urol, Sch Med, Turin, Italy

[11] Charles Univ Prague, Gen Teaching Hosp, Urol, Prague, Czech Republic

[12] Charles Univ Praha, Fac Med 1, Prague, Czech Republic

[13] Charles Univ Prague, Gen Teaching Hosp, Pathol, Prague, Czech Republic

[14] Charles Univ Praha, Fac Med 1, Prague, Czech Republic

[15] Radboud Univ Nijmegen, Urol, Med Ctr, Nijmegen, Netherlands

[16] Zuyderland Med Ctr, Urol, Sittard Heerlen, Netherlands

[17] Radboud Univ Nijmegen, Pathol, Med Ctr, Nijmegen, Netherlands

[18] Charles Univ Praha, Teaching Hosp Motol, Urol, Prague, Czech Republic

[19] Charles Univ Praha, Fac Med 2, Prague, Czech Republic

[20] Fdn Inst Valenciano Oncol IVO, Pathol, Valencia, Spain

[21] Fdn Inst Valenciano Oncol IVO, Urol, Valencia, Spain

[22] Med Univ Graz, Urol, Graz, Austria

[23] Med Univ Graz, Pathol, Graz, Austria

[24] Royal Surrey Hosp, Stokes Ctr Urol, Urol, Guildford, England

[25] Med Univ Vienna, Vienna Gen Hosp, Comprehens Canc Ctr, Urol, Vienna, Austria

[26] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Urol,GRC 5,ONCOTYPE URO, F-75013 Paris, France

[27] Royal Free Hosp, Royal Free London NHS Fdn Trust, Urol, London, England

[28] Sorbonne Univ, Tenon Hosp, AP HP, Urol, Paris, France

[29] Royal Free Hosp, Royal Free London NHS Fdn Trust, Pathol, London, England

[30] Sorbonne Univ, Salpetriere Hosp, AP HP, Pierre & Marie Curie Med Sch,Pathol, Paris, France

[31] Med Univ Vienna, Vienna Gen Hosp, Comprehens Canc Ctr, Pathol, Vienna, Austria

[32] Charles Univ Praha, Teaching Hosp Motol, Pathol, Prague, Czech Republic

[33] Charles Univ Praha, Fac Med 2, Prague, Czech Republic

[34] Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Surg Oncol Urol, Toronto, ON, Canada

[35] Univ Regensburg, Pathol, Regensburg, Germany

[36] Radboud Univ Nijmegen, Hlth Evidence & Urol, Med Ctr, Nijmegen, Netherlands

[37] Univ Torino, Citta Salute & Sci, Pathol, Sch Med, Turin, Italy

[38] Univ Autonoma Barcelona, Pathol, Fundacio Puigvert, Barcelona, Spain

[39] Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Lab Med Program, Toronto, ON, Canada

来源：

INTERNATIONAL UROLOGY AND NEPHROLOGY | 2024年 / 56卷 / 04期

关键词：

Non-muscle invasive bladder cancer; Re-TURB; Second TURB; Repeat TURB; Restaging TURB; Prognosis; TRANSITIONAL-CELL-CARCINOMA; TRANSURETHRAL RESECTION; RECURRENCE; SURVIVAL;

D O I：

10.1007/s11255-023-03867-9

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

PurposeA re-transurethral resection of the bladder (re-TURB) is a well-established approach in managing non-muscle invasive bladder cancer (NMIBC) for various reasons: repeat-TURB is recommended for a macroscopically incomplete initial resection, restaging-TURB is required if the first resection was macroscopically complete but contained no detrusor muscle (DM) and second-TURB is advised for all completely resected T1-tumors with DM in the resection specimen. This study assessed the long-term outcomes after repeat-, second-, and restaging-TURB in T1-NMIBC patients.MethodsIndividual patient data with tumor characteristics of 1660 primary T1-patients (muscle-invasion at re-TURB omitted) diagnosed from 1990 to 2018 in 17 hospitals were analyzed. Time to recurrence, progression, death due to bladder cancer (BC), and all causes (OS) were visualized with cumulative incidence functions and analyzed by log-rank tests and multivariable Cox-regression models stratified by institution.ResultsMedian follow-up was 45.3 (IQR 22.7-81.1) months. There were no differences in time to recurrence, progression, or OS between patients undergoing restaging (135 patients), second (644 patients), or repeat-TURB (84 patients), nor between patients who did or who did not undergo second or restaging-TURB. However, patients who underwent repeat-TURB had a shorter time to BC death compared to those who had second- or restaging-TURB (multivariable HR 3.58, P = 0.004).ConclusionPrognosis did not significantly differ between patients who underwent restaging- or second-TURB. However, a worse prognosis in terms of death due to bladder cancer was found in patients who underwent repeat-TURB compared to second-TURB and restaging-TURB, highlighting the importance of separately evaluating different indications for re-TURB.

引用

页码：1323 / 1333

页数：11

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