Differential associations of clinical features with cerebrospinal fluid biomarkers in dementia with Lewy bodies and Alzheimer's disease

被引：11

作者：

de Oliveira, Fabricio Ferreira ^{[1
]}

Miraldo, Marjorie Camara ^{[1
]}

de Castro-Neto, Eduardo Ferreira ^{[1
]}

de Almeida, Sandro Soares ^{[2
]}

de Andrade Matas, Sandro Luiz ^{[1
]}

Ferreira Bertolucci, Paulo Henrique ^{[1
]}

Naffah-Mazzacoratti, Maria da Graca ^{[1
]}

机构：

[1] Fed Univ Sao Paulo UNIFESP, Escola Paulista Med, Dept Neurol & Neurosurg, Rua Botucatu 740,Vila Clementino, BR-04023900 Sao Paulo, SP, Brazil

[2] Fed Univ Sao Paulo UNIFESP, Escola Paulista Med, Dept Biophys, Sao Paulo, SP, Brazil

来源：

AGING CLINICAL AND EXPERIMENTAL RESEARCH | 2023年 / 35卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

Lewy body dementia; Alzheimer's disease; Cognitive disorders; Activities of daily living; Cerebrospinal fluid; ApoE; DIAGNOSIS; SCALE; BETA; TAU;

D O I：

10.1007/s40520-023-02452-5

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aim To explore associations of cerebrospinal fluid biomarkers of neurodegeneration and amyloidosis with caregiver burden, cognition and functionality in dementia with Lewy bodies (DLB) paired with late-onset Alzheimer's disease (AD) and healthy older people. Methods Consecutive outpatients with DLB were matched with outpatients with AD according to sex, cognitive scores and dementia stage, and with cognitively healthy controls according to age and sex to investigate associations of cerebrospinal fluid amyloid-beta (A beta(42),A beta(40),A beta(38)), tau, phospho-tau Thr(181), ubiquitin, alpha-synuclein and neurofilament light with caregiver burden, functionality, reverse digit span, a clock drawing test, Mini-Mental State Examination (MMSE) and Severe MMSE, adjusted for sex, age, education, dementia duration and APOE-epsilon 4 alleles. Results Overall, 27 patients with DLB (78.98 +/- 9.0 years-old; eleven APOE-epsilon 4+) were paired with 27 patients with AD (81.50 +/- 5.8 years-old; twelve APOE-epsilon 4 +) and 27 controls (78.98 +/- 8.7 years-old; four APOE-epsilon 4+); two-thirds were women. In AD, A beta(42)/A beta(38) and A beta(42) were lower, while tau/A beta(42) and phospho-tau Thr(181)/A beta(42) were higher; alpha-synuclein/A beta(42) was lower in DLB and higher in AD. The following corrected associations remained significant: in DLB, instrumental functionality was inversely associated with tau/phospho-tau Thr(181) and tau/A beta(42), and reverse digit span associated with alpha-synuclein; in AD, instrumental functionality was inversely associated with neurofilament light, clock drawing test scores inversely associated with phospho-tau Thr(181)/A beta(42) and alpha-synuclein/A beta(42), and Severe MMSE inversely associated with tau/A beta(42) and tau/phospho-tau Thr(181). Conclusions Cerebrospinal fluid phospho-tau Thr(181) in DLB was similar to AD, but not A beta(42). In associations with test scores, biomarker ratios were superior to isolated biomarkers, while worse functionality was associated with axonal degeneration only in AD.

引用

页码：1741 / 1752

页数：12

共 43 条

[21] The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

McKhann, Guy M. ;

Knopman, David S. ;

Chertkow, Howard ;

Hyman, Bradley T. ;

Jack, Clifford R., Jr. ;

Kawas, Claudia H. ;

Klunk, William E. ;

Koroshetz, Walter J. ;

Manly, Jennifer J. ;

Mayeux, Richard ;

Mohs, Richard C. ;

Morris, John C. ;

Rossor, Martin N. ;

Scheltens, Philip ;

Carrillo, Maria C. ;

Thies, Bill ;

Weintraub, Sandra ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :263-269

[22] Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study [J].

Murray, Melissa E. ;

Graff-Radford, Neill R. ;

Ross, Owen A. ;

Petersen, Ronald C. ;

Duara, Ranjan ;

Dickson, Dennis W. .

LANCET NEUROLOGY, 2011, 10 (09) :785-796

[23] A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies [J].

Nalls, Michael A. ;

Duran, Raquel ;

Lopez, Grisel ;

Kurzawa-Akanbi, Marzena ;

McKeith, Ian G. ;

Chinnery, Patrick F. ;

Morris, Christopher M. ;

Theuns, Jessie ;

Crosiers, David ;

Cras, Patrick ;

Engelborghs, Sebastiaan ;

De Deyn, Peter Paul ;

Van Broeckhoven, Christine ;

Mann, David M. A. ;

Snowden, Julie ;

Pickering-Brown, Stuart ;

Halliwell, Nicola ;

Davidson, Yvonne ;

Gibbons, Linda ;

Harris, Jenny ;

Sheerin, Una-Marie ;

Bras, Jose ;

Hardy, John ;

Clark, Lorraine ;

Marder, Karen ;

Honig, Lawrence S. ;

Berg, Daniela ;

Maetzler, Walter ;

Brockmann, Kathrin ;

Gasser, Thomas ;

Novellino, Fabiana ;

Quattrone, Aldo ;

Annesi, Grazia ;

De Marco, Elvira Valeria ;

Rogaeva, Ekaterina ;

Masellis, Mario ;

Black, Sandra E. ;

Bilbao, Juan M. ;

Foroud, Tatiana ;

Ghetti, Bernardino ;

Nichols, William C. ;

Pankratz, Nathan ;

Halliday, Glenda ;

Lesage, Suzanne ;

Klebe, Stephan ;

Durr, Alexandra ;

Duyckaerts, Charles ;

Brice, Alexis ;

Giasson, Benoit I. ;

Trojanowski, John Q. .

JAMA NEUROLOGY, 2013, 70 (06) :727-735

[24] Low Levels of Soluble NG2 in Cerebrospinal Fluid from Patients with Dementia with Lewy Bodies [J].

Nielsen, Henrietta M. ;

Hall, Sara ;

Surova, Yulia ;

Nagga, Katarina ;

Nilsson, Christer ;

Londos, Elisabet ;

Minthon, Lennart ;

Hansson, Oskar ;

Wennstrom, Malin .

JOURNAL OF ALZHEIMERS DISEASE, 2014, 40 (02) :343-350

[25] Conversion of amyloid positive and negative MCI to AD over 3 years An 11C-PIB PET study [J].

Okello, A. ;

Koivunen, J. ;

Edison, P. ;

Archer, H. A. ;

Turkheimer, F. E. ;

Nagren, K. ;

Bullock, R. ;

Walker, Z. ;

Kennedy, A. ;

Fox, N. C. ;

Rossor, M. N. ;

Rinne, J. O. ;

Brooks, D. J. .

NEUROLOGY, 2009, 73 (10) :754-760

[26]

Oliveira Fabricio, 2023, Mendeley Data, V1, DOI 10.17632/39XYYJDSF3.1

[27] Contrasts Between Patients With Lewy Body Dementia Syndromes and APOE-ε3/ε3 Patients With Late-onset Alzheimer Disease Dementia [J].

Oliveira, Fabricio F. ;

Machado, Fernando C. ;

Sampaio, Gustavo ;

Marin, Sheilla M. C. ;

Chen, Elizabeth S. ;

Smith, Marilia C. ;

Bertolucci, Paulo H. F. .

NEUROLOGIST, 2015, 20 (02) :35-41

[28] In vivo Prevalence of Alzheimer Biomarkers in Dementia with Lewy Bodies [J].

Paraskevas, George P. ;

Bougea, Anastasia ;

Constantinides, Vasilios C. ;

Bourbouli, Mara ;

Petropoulou, Olga ;

Kapaki, Elisabeth .

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2019, 47 (4-6) :289-296

[29] Parkinson's and Lewy body dementia CSF biomarkers [J].

Parnetti, Lucilla ;

Paciotti, Silvia ;

Farotti, Lucia ;

Bellomo, Giovanni ;

Sepe, Federica Nicoletta ;

Eusebi, Paolo .

CLINICA CHIMICA ACTA, 2019, 495 :318-325

[30] Cerebrospinal fluid in the differential diagnosis of Alzheimer's disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic [J].

Paterson, Ross W. ;

Slattery, Catherine F. ;

Poole, Teresa ;

Nicholas, Jennifer M. ;

Magdalinou, Nadia K. ;

Toombs, Jamie ;

Chapman, Miles D. ;

Lunn, Michael P. ;

Heslegrave, Amanda J. ;

Foiani, Martha S. ;

Weston, Philip S. J. ;

Keshavan, Ashvini ;

Rohrer, Jonathan D. ;

Rossor, Martin N. ;

Warren, Jason D. ;

Mummery, Catherine J. ;

Blennow, Kaj ;

Fox, Nick C. ;

Zetterberg, Henrik ;

Schott, Jonathan M. .

ALZHEIMERS RESEARCH & THERAPY, 2018, 10

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