Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine

被引：15

作者：

Inam, Hina ^{[1
,2
]}

Sprio, Simone ^{[1
]}

Tavoni, Marta ^{[1
,2
]}

Abbas, Zahid ^{[1
,3
]}

Pupilli, Federico ^{[1
,4
]}

Tampieri, Anna ^{[1
]}

机构：

[1] Natl Res Council Italy CNR, Inst Sci Technol & Sustainabil Ceram ISSMC, I-48018 Faenza, Italy

[2] Univ Parma, Dept Mat Sci & Technol, I-43121 Parma, Italy

[3] Univ Bologna, Dept Chem Giacomo Ciamician, I-40126 Bologna, Italy

[4] Univ Padua, Dept Chem Sci, I-35122 Padua, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 05期

关键词：

magnetic hydroxyapatite; synthesis methods; drug delivery; regenerative medicine; nano medicine; IRON-OXIDE NANOPARTICLES; MESENCHYMAL STEM-CELLS; VITRO BIOLOGICAL EVALUATIONS; DRUG-DELIVERY; HYDROTHERMAL SYNTHESIS; NANO-HYDROXYAPATITE; MECHANOCHEMICAL SYNTHESIS; SUBSTITUTED HYDROXYAPATITE; OSTEOGENIC DIFFERENTIATION; MULTIFUNCTIONAL PLATFORM;

D O I：

10.3390/ijms25052809

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review focuses on the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications in nanomedicine and regenerative medicine. mHA nanoparticles have gained significant interest over the last few years for their great potential, offering advanced multi-therapeutic strategies because of their biocompatibility, bioactivity, and unique physicochemical features, enabling on-demand activation and control. The most relevant synthetic methods to obtain magnetic apatite-based materials, either in the form of iron-doped HA nanoparticles showing intrinsic magnetic properties or composite/hybrid compounds between HA and superparamagnetic metal oxide nanoparticles, are described as highlighting structure-property correlations. Following this, this review discusses the application of various magnetic hydroxyapatite nanomaterials in bone regeneration and nanomedicine. Finally, novel perspectives are investigated with respect to the ability of mHA nanoparticles to improve nanocarriers with homogeneous structures to promote multifunctional biological applications, such as cell stimulation and instruction, antimicrobial activity, and drug release with on-demand triggering.

引用

页数：37

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