Palladium(II)-Catalyzed Heck Coupling: Direct Stereoselective Synthesis of C-Aryl Glycosides from Nonactivated Glycals and Thianthrenium Salts

被引：4
作者：
Wei, Xinxin [1 ,2 ]
Zeng, Mingjie [2 ,3 ]
Li, Yazhou [2 ]
Wang, Dechuan [1 ]
Wang, Jiang [2 ,4 ]
Liu, Hong [2 ,3 ]
机构：
[1] China Pharmaceut Univ, Sch Sci, Nanjing 211198, Jiangsu, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
[3] China Pharmaceut Univ, Nanjing 211198, Jiangsu, Peoples R China
[4] Lingang Lab, Shanghai 200031, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 12期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
H FUNCTIONALIZATION; GLYCOSYLATION;
D O I：
10.1021/acs.orglett.4c00654
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here, we report an efficient Pd(II)-catalyzed Heck coupling reaction utilizing modular and readily available thianthrenium salts. The tunability and ease of thianthrenium salts facilitated the integration of glycals with drugs, natural products, and peptides. This method allows the incorporation of diverse glycals into structurally varied aglycon components without directing groups or prefunctionalization and provides a practical method for synthesizing C-aryl glycosides, offering a new avenue for the production of complex glycosides with potential applications.
引用
收藏
页码：2473 / 2477
页数：5
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