Prevalence and Impact of HIV Infections in Patients with Rheumatic Heart Disease: A Systematic Review and Meta-Analysis

被引：2

作者：

Lumngwena, Evelyn N. ^{[1
,2
]}

Mokaila, Dipolelo ^{[3
,4
]}

Aremu, Olukayode ^{[3
,4
]}

Katoto, Patrick D. M. C. ^{[3
,5
,6
]}

Blackburn, Jonathan ^{[7
,8
]}

Zilla, Peter ^{[9
]}

Wiysonge, Charles Shey ^{[5
,10
]}

Ntusi, Ntobeko ^{[3
,4
,11
]}

机构：

[1] Univ Witwatersrand, Sch Clin Med, Fac Hlth Sci, Johannesburg, South Africa

[2] Minist Sci Res & Innovat, Inst Med Res & Med Plant Studies IMPM, Ctr Study Emerging & Re Emerging Infect CREMER, Yaounde, Cameroon

[3] Univ Cape Town, Cape Heart Inst, Dept Med, Fac Hlth Sci, Cape Town, South Africa

[4] Univ Cape Town, Div Cardiol, Dept Med, Fac Hlth Sci, Cape Town, South Africa

[5] South African Med Res Council, Cochrane South Africa, Francie Van Zijl Dr, ZA-7501 Cape Town, South Africa

[6] Catholic Univ Bukavu, Ctr Trop Dis & Global Hlth, Bukavu, DEM REP CONGO

[7] Univ Cape Town, Inst Infect Dis & Mol Med, Fac Hlth Sci, Cape Town, South Africa

[8] Univ Cape Town, Dept Integrat Biomed Sci, Cape Town, South Africa

[9] Univ Cape Town, Christiaan Barnard Div Cardiothorac Surg, Cape Town, South Africa

[10] World Hlth Org Reg Off Africa, Brazzaville, Rep Congo

[11] Univ Cape Town, Cape Univ Body Imaging Ctr, Fac Hlth Sci, Cape Town, South Africa

来源：

GLOBAL HEART | 2023年 / 18卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

rheumatic heart disease; acquired HIV infections; vertical HIV transmission; prevalence; SUB-SAHARAN AFRICA; IMMUNODEFICIENCY-VIRUS-INFECTION; GLOBAL BURDEN; ANTIRETROVIRAL THERAPY; PULMONARY-HYPERTENSION; CARDIOVASCULAR-DISEASE; CARDIAC-DISEASE; RISK; MANAGEMENT; CHILDREN;

D O I：

10.5334/gh.1265

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Socioeconomic factors such as poor health and poor nutrition in low- and middle-income countries (LMICs) may favour inflammatory reactions, thus contributing to the recurrence of rheumatic fever (RF) and thereby modifying trends in rheumatic heart disease (RHD). Apart from epidemiological studies, studies of HIV infections in RHD patients are limited. This systematic review synthesises data on the prevalence and impact of HIV infections or AIDS on RHD from PubMed, Scopus, Web of Science databases up to April 2021. The outcomes were managed using PRISMA guidelines. Of a total of 15 studies found, 10 were eligible for meta-analyses. Meta-analysis found that 17% (95 % CI 8-33, I-2 = 91%) of adults in cardiovascular disease (CVD) cohorts in Southern Africa are HIV positive. The proportion of RHD diagnosed among people living with HIV was 4% (95% CI 2-8, I-2 = 79%) for adults but lower [2% (95% CI 1-4, I-2 = 87%)] among perinatally infected children. Despite limited reporting, HIV-infected patients with RHD are prone to other infections that may enhance cardiac complications due to poor immunological control.

引用

页数：18

共 88 条

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