The role of vasoactive intestinal peptide in pulmonary diseases

被引：7

作者：

Zhong, Hong-Lin ^{[1
]}

Li, Pei-Ze ^{[1
]}

Li, Di ^{[1
]}

Guan, Cha-Xiang ^{[1
]}

Zhou, Yong ^{[1
]}

机构：

[1] Cent South Univ, Sch Basic Med Sci, Dept Physiol, Changsha 410078, Hunan, Peoples R China

来源：

LIFE SCIENCES | 2023年 / 332卷

基金：

中国国家自然科学基金;

关键词：

Vasoactive intestinal peptide; Pulmonary arterial hypertension; Chronic obstructive pulmonary disease; Acute respiratory distress syndrome; Lung cancer; CYCLASE-ACTIVATING POLYPEPTIDE; VIP RECEPTOR AGONISTS; ARTERIAL-HYPERTENSION; SMOOTH-MUSCLE; IN-VITRO; ANTIINFLAMMATORY ACTIVITY; SELECTIVE ANTAGONIST; MEDIATED INHIBITION; MICE LACKING; LUNG;

D O I：

10.1016/j.lfs.2023.122121

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Vasoactive intestinal peptide (VIP) is an abundant neurotransmitter in the lungs and other organs. Its discovery dates back to 1970. And VIP gains attention again due to the potential application in COVID-19 after a research wave in the 1980s and 1990s. The diverse biological impacts of VIP extend beyond its usage in COVID-19 treatment, encompassing its involvement in various pulmonary and systemic disorders. This review centers on the function of VIP in various lung diseases, such as pulmonary arterial hypertension, chronic obstructive pulmonary disease, asthma, cystic fibrosis, acute lung injury/acute respiratory distress syndrome, pulmonary fibrosis, and lung tumors. This review also outlines two main limitations of VIP as a potential medication and gathers information on extended-release formulations and VIP analogues.

引用

页数：16

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