Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report

被引：1
作者：
Suarez, Amaranto [1 ]
Soler, Nathalie [2 ]
Calderon, Alejandra [2 ]
Martinez, Bibiana [3 ]
Pina, Martha [2 ]
机构：
[1] Inst Nacl Cancerol, Pediat Oncol, Bogota, Colombia
[2] Inst Nacl Cancerol, Pediat Oncol, Bogota, Colombia
[3] Inst Nacl Cancerol, Haematol, Bogota, Colombia
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 02期
关键词：
morphology; clinics; leukemia; pediatric; blastic plasmacytoid dendritic cell neoplasm; LEUKEMIA;
D O I：
10.7759/cureus.34549
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but aggressive malignancy with high mortality involving the skin and hematopoietic system. Clinical suspicion is difficult, and management of skin lesions is challenging due to their indolent course prior to dissemination. We describe a patient with isolated skin involvement who progressed to CD4+/CD56+ and CD123+ acute leukemia.
引用
收藏
页数：6
相关论文
共 20 条
  • [1] HIGH EXPRESSION OF CD56 (N-CAM) IN A PATIENT WITH CUTANEOUS CD4-POSITIVE LYMPHOMA
    ADACHI, M
    MAEDA, K
    TAKEKAWA, M
    HINODA, Y
    IMAI, K
    SUGIYAMA, S
    YACHI, A
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 1994, 47 (04) : 278 - 282
  • [2] Immunophenotypic Analysis of Myeloperoxidase-Negative Leukemia Cutis and Blastic Plasmacytoid Dendritic Cell Neoplasm
    Cronin, Danielle M. P.
    George, Tracy I.
    Reichard, Kaaren K.
    Sundram, Uma N.
    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2012, 137 (03) : 367 - 376
  • [3] Blastic Plasmacytoid Dendritic Cell Neoplasm Clinical Presentation and Diagnosis
    Deconinck, Eric
    Petrella, Tony
    Ottou, Francine Garnache
    [J]. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2020, 34 (03) : 491 - 500
  • [4] Facchetti F., 2008, WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues, V4th, P145
  • [5] Facchetti F., 2017, WHO CLASSIFICATION T, P174
  • [6] Clinical and biologic features of CD4+CD56+ malignancies
    Feuillard, J
    Jacob, MC
    Valensi, F
    Maynadié, M
    Gressin, R
    Chaperot, L
    Arnoulet, C
    Brignole-Baudouin, F
    Drénou, B
    Duchayne, E
    Falkenrodt, A
    Garand, R
    Homolle, E
    Husson, B
    Kuhlein, E
    Le Calvez, G
    Sainty, D
    Sotto, MF
    Trimoreau, F
    Béné, MC
    [J]. BLOOD, 2002, 99 (05) : 1556 - 1563
  • [7] Infantile CD4+/CD56+ hematodermic neoplasm
    Hu, Stephen Chu-Sung
    Tsai, Kun-Bow
    Chen, Gwo-Shing
    Chen, Po-Hung
    [J]. HAEMATOLOGICA, 2007, 92 (09) : E91 - E93
  • [8] Blastic plasmacytoid dendritic cell neoplasm in children: diagnostic features and clinical implications
    Jegalian, Armin G.
    Buxbaum, Nataliya P.
    Facchetti, Fabio
    Raffeld, Mark
    Pittaluga, Stefania
    Wayne, Alan S.
    Jaffe, Elaine S.
    [J]. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 (11): : 1873 - 1879
  • [9] FDA Approval Summary: Tagraxofusp-erzs For Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm
    Jen, Emily Y.
    Gao, Xin
    Li, Liang
    Zhuang, Luning
    Simpson, Natalie E.
    Aryal, Baikuntha
    Wang, Rong
    Przepiorka, Donna
    Shen, Yuan Li
    Leong, Ruby
    Liu, Chao
    Sheth, Christopher M.
    Bowen, Steven
    Goldberg, Kirsten B.
    Farrell, Ann T.
    Blumenthal, Gideon M.
    Pazdur, Richard
    [J]. CLINICAL CANCER RESEARCH, 2020, 26 (03) : 532 - 536
  • [10] Blastic plasmacytoid dendritic cell neoplasm: clinical features in 90 patients
    Julia, F.
    Petrella, T.
    Beylot-Barry, M.
    Bagot, M.
    Lipsker, D.
    Machet, L.
    Joly, P.
    Dereure, O.
    Wetterwald, M.
    d'Incan, M.
    Grange, F.
    Cornillon, J.
    Tertian, G.
    Maubec, E.
    Saiag, P.
    Barete, S.
    Templier, I.
    Aubin, F.
    Dalle, S.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2013, 169 (03) : 579 - 586
12