Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review

被引：115
作者：
Al-Qahtani, Arwa A. [1 ]
Alhamlan, Fatimah S. [2 ,3 ]
Al-Qahtani, Ahmed Ali [2 ,3 ]
机构：
[1] Al Imam Mohammad Ibn Saud Islamic Univ, Coll Med, Dept Family Med, Riyadh 11432, Saudi Arabia
[2] King Faisal Specialist Hosp & Res Ctr, Dept Infect & Immun, Riyadh 11211, Saudi Arabia
[3] Alfaisal Univ, Coll Med, Dept Microbiol & Immunol, Riyadh 11211, Saudi Arabia
来源：
TROPICAL MEDICINE AND INFECTIOUS DISEASE | 2024年 / 9卷 / 01期
关键词：
interleukins; infectious diseases; pro-inflammatory; anti-inflammatory; immune response; diagnosis; therapy; REGULATORY T-CELLS; IFN-GAMMA; IL-10; IMMUNITY; INNATE; PROGRESSION; INHIBITION; RESPONSES; DEFENSE; SEPSIS;
D O I：
10.3390/tropicalmed9010013
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Interleukins (ILs) are signaling molecules that are crucial in regulating immune responses during infectious diseases. Pro-inflammatory ILs contribute to the activation and recruitment of immune cells, whereas anti-inflammatory ILs help to suppress excessive inflammation and promote tissue repair. Here, we provide a comprehensive overview of the role of pro-inflammatory and anti-inflammatory ILs in infectious diseases, with a focus on the mechanisms underlying their effects, their diagnostic and therapeutic potential, and emerging trends in IL-based therapies.
引用
收藏
页数：20
相关论文
共 155 条
[101]   IL-10: Achieving Balance During Persistent Viral Infection [J].
Ng, Cherie T. ;
Oldstone, Michael B. A. .
INTERLEUKIN-10 IN HEALTH AND DISEASE, 2014, 380 :129-144
[102]   Elevated interleukin (IL)-6 as a predictor of disease severity among Covid-19 patients: a prospective cohort study [J].
Nikkhoo, Bahram ;
Mohammadi, Matin ;
Hasani, Sabah ;
Sigari, Naseh ;
Borhani, Aryan ;
Ramezani, Chia ;
Charajoo, Arian ;
Badri, Shaho ;
Rostami, Farzin ;
Etemadi, Mashala ;
Rahmani, Khaled .
BMC INFECTIOUS DISEASES, 2023, 23 (01)
[103]   IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria [J].
Otterdal, Kari ;
Berg, Aase ;
Michelsen, Annika E. ;
Yndestad, Arne ;
Patel, Sam ;
Gregersen, Ida ;
Halvorsen, Bente ;
Ueland, Thor ;
Langeland, Nina ;
Aukrust, Pal .
BMC INFECTIOUS DISEASES, 2021, 21 (01)
[104]   HIV-associated chronic immune activation [J].
Paiardini, Mirko ;
Mueller-Trutwin, Michaela .
IMMUNOLOGICAL REVIEWS, 2013, 254 :78-101
[105]   Saikosaponin C exerts anti-HBV effects by attenuating HNF1α and HNF4α expression to suppress HBV pgRNA synthesis [J].
Pan, Yanchao ;
Ke, Zhiyi ;
Ye, Hong ;
Sun, Lina ;
Ding, Xiaoyan ;
Shen, Yun ;
Zhang, Runze ;
Yuan, Jing .
INFLAMMATION RESEARCH, 2019, 68 (12) :1025-1034
[106]   Dupilumab: human monoclonal antibody against IL-4Rα for moderate to severe atopic dermatitis [J].
Paton, D. M. .
DRUGS OF TODAY, 2017, 53 (09) :477-487
[107]   Interleukin-1 receptor antagonist (IL-1RA) and interleukin-4 (IL-4) variable number of tandem repeat polymorphisms in schizophrenia and bipolar disorder: an association study in Turkish population [J].
Pehlivan, Sacide ;
Oyaci, Yasemin ;
Tuncel, Fatima Ceren ;
Aytac, Hasan Mervan .
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS, 2022, 23 (01)
[108]  
Pelechas Eleftherios, 2020, Mediterr J Rheumatol, V31, P259, DOI 10.31138/mjr.31.3.259
[109]   PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection [J].
Perry, Joseph A. ;
Shallberg, Lindsey ;
Clark, Joseph T. ;
Gullicksrud, Jodi A. ;
DeLong, Jonathan H. ;
Douglas, Bonnie B. ;
Hart, Andrew P. ;
Lanzar, Zachary ;
O'Dea, Keenan ;
Konradt, Christoph ;
Park, Jeongho ;
Kuchroo, Juhi R. ;
Grubaugh, Daniel ;
Zaretsky, Arielle Glatman ;
Brodsky, Igor E. ;
Malefyt, Rene de Waal ;
Christian, David A. ;
Sharpe, Arlene H. ;
Hunter, Christopher A. .
NATURE IMMUNOLOGY, 2022, 23 (05) :743-+
[110]   The Regulatory Role of IL-10 in Neurodegenerative Diseases [J].
Porro, Chiara ;
Cianciulli, Antonia ;
Panaro, Maria Antonietta .
BIOMOLECULES, 2020, 10 (07) :1-15
6789101112131415