Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.

被引：0
作者：
Alkhalili, Samer [1 ]
Manogna, Dharmini [2 ]
Safah, Hana [2 ]
Ellent, Elizabeth [3 ]
Beversdorf, Walter [4 ,5 ]
Arora, Ruby [6 ]
Saba, Nakhle S. [2 ,7 ]
机构：
[1] Tulane Univ, Sch Med, Deming Dept Med, 1430 Tulane Ave, New Orleans, LA 70112 USA
[2] Tulane Univ, Sch Med, Deming Dept Med, Sect Hematol Med Oncol, 1430 Tulane Ave, New Orleans, LA 70112 USA
[3] LCMC Hlth, Hematol & Med Oncol, 4513 Westbank Expressway, Marrero, LA 70072 USA
[4] Tulane Univ, Sch Med, Dept Pathol, 1430 Tulane Ave, New Orleans, LA 70112 USA
[5] Tulane Univ, Lab Med, Sch Med, 1430 Tulane Ave, New Orleans, LA 70112 USA
[6] Tulane Univ, Sch Med, 1430 Tulane Ave, New Orleans, LA 70112 USA
[7] Sch Med, Deming Dept Med, Sect Hematol & Med Oncol, 1430 Tulane Ave 8578, New Orleans, LA 70112 USA
来源：
LEUKEMIA RESEARCH REPORTS | 2023年 / 20卷
关键词：
MCL; Testicular lymphoma; PTL; NHL; Cyclin-D1; FEATURES;
D O I：
10.1016/j.lrr.2023.100397
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mantle cell lymphoma (MCL) with testicular involvement is a rare presentation and only a few cases have been described in the literature. We present a case of MCL with testicular involvement and the first analysis of all previously reported cases assessing trends in immunohistochemical features, prognostic indicators, and survival. Our data suggest that among all MCL, testicular MCL is more likely to present with aggressive features: blastoid/ pleomorphic morphology, high Ki-67 proliferative index, and CNS involvement. Testicular MCL is also associated with shorter overall survival.
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