Patient-Related Factors Predicting Stent Thrombosis in Percutaneous Coronary Interventions

被引:9
作者
Anghel, Larisa [1 ,2 ]
Tudurachi, Bogdan-Sorin [1 ,2 ]
Tudurachi, Andreea [2 ]
Zavoi, Alexandra [2 ]
Clement, Alexandra [1 ,2 ]
Roungos, Alexandros [2 ]
Benchea, Laura-Catalina [1 ,2 ]
Zota, Ioana Madalina [1 ,2 ]
Prisacariu, Cristina [1 ,2 ]
Sascau, Radu Andy [1 ,2 ]
Statescu, Cristian [1 ,2 ]
机构
[1] Grigore T Popa Univ Med & Pharm, Internal Med Dept, Iasi 700503, Romania
[2] Cardiovasc Dis Inst Prof Dr George IM Georgescu, Cardiol Dept, Iasi 700503, Romania
关键词
stent thrombosis; patient-related factors; percutaneous coronary intervention; cardiac death; heart attack; DUAL-ANTIPLATELET THERAPY; DRUG-ELUTING STENTS; ACUTE MYOCARDIAL-INFARCTION; CHRONIC HEART-FAILURE; DIABETES-MELLITUS; RISK SCORE; CLOPIDOGREL; OUTCOMES; DISEASE; EVENTS;
D O I
10.3390/jcm12237367
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Over the past four decades, percutaneous coronary intervention (PCI) safety and efficacy have significantly improved, particularly with the advent of the drug-eluting stent (DES). First-generation DESs reduced in-stent restenosis rates and targeted lesion revascularization; however, safety issues emerged, due to high incidences of stent thrombosis (ST) linked to death, myocardial infarction, and repeat revascularization. Second-generation DESs were developed to overcome these issues, reducing late-thrombotic-event risk while maintaining anti-restenosis efficacy. Nevertheless, ST still occurs with second-generation DES use. Stent thrombosis etiology is multifaceted, encompassing lesion-, patient-, procedural-, and stent-related factors. Overall, most early-stent-thrombosis cases are linked to procedural and patient-related aspects. Factors like premature discontinuation of dual antiplatelet therapy, resistance to clopidogrel, smoking, diabetes mellitus, malignancy, reduced ejection fraction or undertaking coronary angioplasty for an acute coronary syndrome can increase the risk of stent thrombosis. The aim of this study is to assess patient-related factors that potentially heighten the risk of stent thrombosis, with the objective of pinpointing and addressing modifiable contributors to this risk. By focusing on both patient- and procedure-related factors, a multifaceted approach to coronary revascularization can help minimize complications and maximize long-term benefits in managing ST.
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页数:21
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  • [1] Effect of diabetes mellitus on formation of coronary collateral vessels
    Abaci, A
    Oguzhan, A
    Kahraman, S
    Eryol, NK
    Ünal, S
    Arinç, H
    Ergin, A
    [J]. CIRCULATION, 1999, 99 (17) : 2239 - 2242
  • [2] Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis A Report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort)
    Adriaenssens, Tom
    Joner, Michael
    Godschalk, Thea C.
    Malik, Nikesh
    Alfonso, Fernando
    Xhepa, Erion
    De Cock, Dries
    Komukai, Kenichi
    Tada, Tomohisa
    Cuesta, Javier
    Sirbu, Vasile
    Feldman, Laurent J.
    Neumann, Franz-Josef
    Goodall, Alison H.
    Heestermans, Ton
    Buysschaert, Ian
    Hlinomaz, Ota
    Belmans, Ann
    Desmet, Walter
    ten Berg, Jurrien M.
    Gershlick, Anthony H.
    Massberg, Steffen
    Kastrati, Adnan
    Guagliumi, Giulio
    Byrne, Robert A.
    [J]. CIRCULATION, 2017, 136 (11) : 1007 - +
  • [3] Cytochrome 2C19 and paraoxonase-1 polymorphisms and clopidogrel resistance in ischemic heart disease patients
    Akram, Nabila
    Mustafa, Ghulam
    Hanif, Anum A.
    Tawwab, Shahzad
    Hussain, Shabbir
    Kaul, Haiba
    Mohsin, Shahida
    [J]. PERSONALIZED MEDICINE, 2019, 16 (05) : 379 - 386
  • [4] Efficacy and Safety Outcomes of Short Duration Antiplatelet Therapy with Early Cessation of Aspirin Post Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis
    Al-Obaidi, Firas R.
    Hutchings, Hayley A.
    Yong, Andy S. C.
    Alrubaiy, Laith
    Al-Farhan, Hasan
    Al-Ali, Mohammed H.
    Al-Kinani, Tahsin
    Al-Myahi, Mohammed
    Al-Kenzawi, Hussein
    Al-Sudani, Nazar
    [J]. CURRENT CARDIOLOGY REVIEWS, 2021, 17 (06)
  • [5] Bedside testing of CYP2C19 gene for treatment of patients with PCI with antiplatelet therapy
    Al-Rubaish, Abdullah M.
    Al-Muhanna, Fahad A.
    Alshehri, Abdullah M.
    Al-Mansori, Mohammed A.
    Alali, Rudaynah A.
    Khalil, Rania M.
    Al Faraidy, Khalid A.
    Cyrus, Cyril
    Sulieman, Mohammed M.
    Vatte, Chittibabu
    Claassens, Daniel M. F.
    ten Berg, Jurrien M.
    Asselbergs, Folkert W.
    Al-Ali, Amein K.
    [J]. BMC CARDIOVASCULAR DISORDERS, 2020, 20 (01)
  • [6] High on-clopidogrel platelet reactivity in ischaemic stroke or transient ischaemic attack: Systematic review and meta-analysis
    Alakbarzade, Vafa
    Huang, Xuya
    Ster, Irina Chis
    McEntagart, Meriel
    Pereira, Anthony C.
    [J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2020, 29 (07)
  • [7] Platelet Hyperreactivity in Diabetes: Focus on GPVI Signaling - Are Useful Drugs Already Available?
    Arthur, Jane F.
    Jandeleit-Dahm, Karin
    Andrews, Robert K.
    [J]. DIABETES, 2017, 66 (01) : 7 - 13
  • [8] Incidence, Patterns, and Impact of Dual Antiplatelet Therapy Cessation Among Patients With and Without Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention Results From the PARIS Registry (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients)
    Baber, Usman
    Li, Shawn X.
    Pinnelas, Rebecca
    Pocock, Stuart J.
    Krucoff, Mitchell W.
    Ariti, Cono
    Gibson, C. Michael
    Steg, Philippe Gabriel
    Weisz, Giora
    Witzenbichler, Bernhard
    Henry, Timothy D.
    Kini, Annapoorna S.
    Stuckey, Thomas
    Cohen, David J.
    Iakovou, Ioannis
    Dangas, George
    Aquino, Melissa B.
    Sartori, Samantha
    Chieffo, Alaide
    Moliterno, David J.
    Colombo, Antonio
    Mehran, Roxana
    [J]. CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2018, 11 (03)
  • [9] Atherothrombosis, inflammation, and diabetes
    Biondi-Zoccai, GGL
    Abbate, A
    Liuzzo, G
    Biasucci, LM
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 41 (07) : 1071 - 1077
  • [10] Hypoxia as a modulator of cytochromes P450: Overexpression of the cytochromes CYP2S1 and CYP24A1 in human liver cancer cells in hypoxia
    Cabrera-Cano, Alfredo
    Manuel Davila-Borja, Victor
    Juarez-Mendez, Sergio
    Marcial-Quino, Jaime
    Gomez-Manzo, Saul
    Angelica Castillo-Rodriguez, Rosa
    [J]. CELL BIOCHEMISTRY AND FUNCTION, 2021, 39 (04) : 478 - 487