The role of EZH2 in ocular diseases: a narrative review

被引：2
作者：
Peng, Yu [1 ]
Bui, Christine H. T. [1 ]
Zhang, Xiu J. [1 ]
Chen, Jian S. [4 ,5 ,6 ]
Tham, Clement C. [1 ,2 ,7 ,8 ]
Chu, Wai K. [1 ,8 ]
Chen, Li J. [1 ,7 ,8 ]
Pang, Chi P. [1 ,8 ]
Yam, Jason C. [1 ,2 ,3 ,7 ,8 ]
机构：
[1] Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong 999077, Peoples R China
[2] Hong Kong Eye Hosp, Kowloon, Hong Kong 999077, Peoples R China
[3] Hong Kong Childrens Hosp, Dept Ophthalmol, Hong Kong 999077, Peoples R China
[4] Cent South Univ, Aier Sch Ophthalmol, Changsha 410000, Hunan, Peoples R China
[5] Aier Eye Inst, Changsha 410000, Hunan, Peoples R China
[6] Jinan Univ, Key Lab Regenerat Med, Minist Educ, Guangzhou 510000, Guangdong, Peoples R China
[7] Prince Wales Hosp, Dept Ophthalmol & Visual Sci, Hong Kong 999077, Peoples R China
[8] Chinese Univ Hong Kong, Hong Kong Hub Paediat Excellence, Hong Kong 999077, Peoples R China
来源：
EPIGENOMICS | 2023年 / 15卷 / 09期
关键词：
age-related retinal degeneration; cataract; corneal injury; diabetic retinopathy; EZH2; glaucoma; inherited retinal diseases; ocular diseases; ocular tumors; retinal development; UVEAL MELANOMA; HISTONE METHYLTRANSFERASE; THERAPEUTIC TARGET; TUMOR-SUPPRESSOR; PROTEIN EZH2; OPEN-LABEL; ALU RNA; METHYLATION; INHIBITOR; PHOSPHORYLATION;
D O I：
10.2217/epi-2023-0147
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Plain language summaryEZH2 is a protein that helps to regulate the activity of genes in cells. It works as a part of a complex called PRC2 to control a chemical group called lysine 27 in histone H3 and then inhibit the expression of genes. EZH2 is important for the normal development of the retina. Abnormal levels of EZH2 are associated with various eye diseases. This review summarizes the role of EZH2 in different ocular diseases and the potential mechanisms. Targeting EZH2 may be a novel way to treat or prevent ocular diseases. Tweetable abstractReview discussing the role of EZH2 in retinal development and ocular diseases to highlight the potential of EZH2 as a precision therapeutic target for treating ocular diseases. EZH2, acting as a catalytic subunit of PRC2 to catalyze lysine 27 in histone H3, induces the suppression of gene expression. EZH2 can regulate cell proliferation and differentiation of retinal progenitors, which are required for physiological retinal development. Meanwhile, an abnormal level of EZH2 has been observed in ocular tumors and other pathological tissues. This review summarizes the current knowledge on EZH2 in retinal development and ocular diseases, including inherited retinal diseases, ocular tumors, corneal injury, cataract, glaucoma, diabetic retinopathy and age-related retinal degeneration. We highlight the potential of targeting EZH2 as a precision therapeutic target in ocular diseases.
引用
收藏
页码：557 / 570
页数：14
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