The C-reactive Protein to Prealbumin Ratio Is an Independent Prognostic Factor for Patients With Gastric Cancer Who Receive Curative Surgery

被引:3
作者
Aoyama, Toru [1 ,2 ]
Hashimoto, Itaru [1 ,2 ]
Maezawa, Yukio [1 ,2 ]
Hara, Kentaro [1 ,3 ]
Komori, Keisuke [1 ]
Otani, Kazuki [1 ]
Kazama, Keisuke [1 ]
Sawazaki, Sho [1 ]
Numata, Masakatsu [1 ]
Kamiya, Natsumi [1 ]
Kato, Aya [1 ]
Yamada, Takanobu [1 ,2 ]
Nagasawa, Shinsuke [1 ]
Kawahara, Shinnosuke [1 ]
Cho, Haruhiko [1 ,3 ]
Morita, Junya [1 ]
Tanabe, Mie [1 ]
Yukawa, Norio [1 ]
Saito, Aya [1 ]
Rino, Yasushi [1 ]
Ogata, Takashi [2 ]
Oshima, Takashi [1 ,2 ]
机构
[1] Yokohama City Univ, Dept Surg, Yokohama, Japan
[2] Kanagawa Canc Ctr, Dept Gastrointestinal Surg, Yokohama, Japan
[3] Komagome Hosp, Dept Surg, Tokyo Metropolitan Canc & Infect Dis Ctr, Tokyo, Japan
关键词
C-reactive protein; prealbumin; gastric cancer; CLINICAL IMPACT; CHEMOTHERAPY;
D O I
10.21873/anticanres.16719
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background/Aim: The C-reactive protein to prealbumin ratio (CPAR) has been proposed and introduced in gastrointestinal cancer management. This study aimed to evaluate the clinical impact of the CPAR in patients with gastric cancer (GC) who received curative treatment. Patients and Methods: This study included 447 patients who underwent curative treatment for GC between 2013 and 2017. The prognosis and clinicopathological parameters were compared between patients with high and low CPARs. Results: Overall survival (OS) stratified by each clinical factor was compared using the log-rank test, and a significant difference was observed using a pretreatment CPAR of 5.0. Significant differences were observed in the 3and 5-year OS rates of the CPAR-low (CPAR <5.0) and CPAR-high (CPAR >= 5.0) groups. The 3- and 5-year OS rates were 92.6% and 87.8%, respectively, in the CPAR-low group and 88.0% and 75.4% in the CPAR-high group. The CPAR was determined to be a significant prognostic factor for OS in a multivariate analysis (p=0.032). Similar results were observed for recurrence-free survival. Conclusion: The CAPR is a prognostic factor for GC patients. Therefore, the CAPR may be a promising nutritional biomarker of inflammation that can be applied in the management of GC patients.
引用
收藏
页码:5181 / 5187
页数:7
相关论文
共 50 条
  • [31] Preoperative elevation of serum C-reactive protein as an independent prognostic indicator for gastric cancer
    Nozoe, Tadahiro
    Iguchi, Tomohiro
    Adachi, Eisuke
    Matsukuma, Akito
    Ezaki, Takahiro
    SURGERY TODAY, 2011, 41 (04) : 510 - 513
  • [32] Clinical significance and prognostic value of C-reactive protein/albumin ratio in gastric cancer
    Yu, Qian
    Li, Ke-zhi
    Fu, Yan-jun
    Tang, Yanping
    Liang, Xin-qiang
    Liang, Zhi-qing
    Bai, Ji-hong
    ANNALS OF SURGICAL TREATMENT AND RESEARCH, 2021, 100 (06) : 338 - 346
  • [33] Neutrophil-to-lymphocyte ratio and C-reactive protein-to-albumin ratio as prognostic factors for unresectable advanced or recurrent gastric cancer
    Namikawa, Tsutomu
    Shimizu, Shigeto
    Yokota, Keiichiro
    Tanioka, Nobuhisa
    Munekage, Masaya
    Uemura, Sunao
    Maeda, Hiromichi
    Kitagawa, Hiroyuki
    Kobayashi, Michiya
    Hanazaki, Kazuhiro
    LANGENBECKS ARCHIVES OF SURGERY, 2022, 407 (02) : 609 - 621
  • [34] Is C-reactive protein a prognostic factor of colorectal cancer?
    Shiu, Yu-Chen
    Lin, Jen-Kou
    Huang, Chi-Jung
    Jiang, Jeng-Kai
    Wang, Ling-Wei
    Huang, Huei-Chen
    Yang, Shung-Haur
    DISEASES OF THE COLON & RECTUM, 2008, 51 (04) : 443 - 449
  • [35] C-Reactive Protein-to-Prealbumin and C-Reactive Protein-to-Albumin Ratios as Nutritional and Prognostic Markers in Hospitalized Patients-An Observational Study
    Garcia-Moreno, Rosa M.
    Reyes, Laura Mola
    Lopez-Plaza, Bricia
    Milla, Samara Palma
    NUTRIENTS, 2024, 16 (16)
  • [36] Pediatric perforated appendicitis diagnosis based on the C-reactive protein/prealbumin ratio
    Junshan Long
    Jing Zhang
    Gong Chen
    Xiaoxia Su
    Baowei Qiu
    Qi Dong
    Scientific Reports, 14
  • [37] Pediatric perforated appendicitis diagnosis based on the C-reactive protein/prealbumin ratio
    Long, Junshan
    Zhang, Jing
    Chen, Gong
    Su, Xiaoxia
    Qiu, Baowei
    Dong, Qi
    SCIENTIFIC REPORTS, 2024, 14 (01)
  • [38] The C-reactive protein to albumin ratio predicts postoperative complication in patients who undergo gastrectomy for gastric cancer
    Lee, Jin Won
    Sharma, Ashish Ranjan
    Lee, Sang-Soo
    Chun, Wan Joo
    Kim, Hae Sung
    HELIYON, 2020, 6 (06)
  • [39] Prognostic Value of C-Reactive Protein, Glasgow Prognostic Score, and C-Reactive Protein-to-Albumin Ratio in Colorectal Cancer
    Zhou, Jiahui
    Wei, Wene
    Hou, Hu
    Ning, Shufang
    Li, Jilin
    Huang, Baoyue
    Liu, Kaisheng
    Zhang, Litu
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [40] Neutrophil-to-lymphocyte ratio and C-reactive protein–to–albumin ratio as prognostic factors for unresectable advanced or recurrent gastric cancer
    Tsutomu Namikawa
    Shigeto Shimizu
    Keiichiro Yokota
    Nobuhisa Tanioka
    Masaya Munekage
    Sunao Uemura
    Hiromichi Maeda
    Hiroyuki Kitagawa
    Michiya Kobayashi
    Kazuhiro Hanazaki
    Langenbeck's Archives of Surgery, 2022, 407 : 609 - 621