Cell-derived biomimetic nanoparticles for the targeted therapy of ALI/ARDS

被引:4
|
作者
Gao, Rui [1 ]
Lin, Peihong [1 ]
Fang, Zhengyu [1 ]
Yang, Wenjing [1 ]
Gao, Wenyan [1 ,2 ]
Wang, Fangqian [1 ]
Pan, Xuwang [3 ]
Yu, Wenying [1 ,2 ]
机构
[1] Hangzhou Med Coll, Sch Pharm, Hangzhou 310013, Peoples R China
[2] Hangzhou Med Coll, Key Lab Neuropsychiat Drug Res Zhejiang Prov, Hangzhou 310013, Peoples R China
[3] Zhejiang Univ, Affiliated Hangzhou Xixi Hosp, Dept Pharmaceut Preparat, Sch Med, Hangzhou 310013, Peoples R China
关键词
ALI/ARDS; Biomimetic nanotechnology; Cell membrane; Extracellular vesicle; Targeted delivery; ENDOTHELIAL PROGENITOR CELLS; ACUTE LUNG INJURY; MESENCHYMAL STROMAL CELLS; STEM-CELLS; DELIVERY; INFLAMMATION; EXOSOMES; LIPOPOLYSACCHARIDE; MICROVESICLES; REPAIR;
D O I
10.1007/s13346-023-01494-6
中图分类号
TH7 [仪器、仪表];
学科分类号
0804 ; 080401 ; 081102 ;
摘要
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common clinical critical diseases with high morbidity and mortality. Especially since the COVID-19 outbreak, the mortality rates of critically ill patients with ARDS can be as high as 60%. Therefore, this problem has become a matter of concern to respiratory critical care. To date, the main clinical measures for ALI/ARDS are mechanical ventilation and drug therapy. Although ventilation treatment reduces mortality, it increases the risk of hyperxemia, and drug treatment lacks safe and effective delivery methods. Therefore, novel therapeutic strategies for ALI/ARDS are urgently needed. Developments in nanotechnology have allowed the construction of a safe, efficient, precise, and controllable drug delivery system. However, problems still encounter in the treatment of ALI/ARDS, such as the toxicity, poor targeting ability, and immunogenicity of nanomaterials. Cell-derived biomimetic nanodelivery drug systems have the advantages of low toxicity, long circulation, high targeting, and high bioavailability and show great therapeutic promises for ALI/ARDS owing to their acquired cellular biological features and some functions. This paper reviews ALI/ARDS treatments based on cell membrane biomimetic technology and extracellular vesicle biomimetic technology, aiming to achieve a significant breakthrough in ALI/ARDS treatments.
引用
收藏
页码:1432 / 1457
页数:26
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