Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series

被引：9
作者：
Fang, Zhixiong [1 ]
Liu, Qiong [2 ]
Tang, Wei [1 ]
Yu, Hongyin [3 ]
Zou, Min [4 ]
Zhang, Haiming [1 ]
Xue, Haiyan [1 ]
Lin, Sha [1 ]
Pei, Yi [5 ]
Ai, Jingwen [6 ]
Chen, Jun [7 ]
机构：
[1] Cent Hosp Xiangtan, Dept Infect Dis & Publ Hlth, Xiangtan, Hunan, Peoples R China
[2] Linxiang Peoples Hosp, Yueyang, Hunan, Peoples R China
[3] First Peoples Hosp Huaihua, Ctr Infect Dis, Huaihua, Hunan, Peoples R China
[4] Nanhua Univ, Peoples Hosp Xiangtan City 1, Dept Resp & Crit Care Med, Hengyang, Hunan, Peoples R China
[5] Changsha Cent Hosp, Dept TB, Changsha, Peoples R China
[6] Fudan Univ, Huashan Hosp, Dept Infect Dis, Shanghai, Peoples R China
[7] Southern Univ Sci & Technol, Hosp Shenzhen 3, Affiliated Hosp 2, Dept Liver Dis, Shenzhen, Guangdong, Peoples R China
来源：
HELIYON | 2023年 / 9卷 / 06期
关键词：
Tropheryma whipplei; Metagenomic next-generation sequencing; Bronchoalveolar lavage fluid; Pneumonia; 1ST ISOLATION; DISEASE; TRIMETHOPRIM; INVOLVEMENT; SALIVA; FLUID;
D O I：
10.1016/j.heliyon.2023.e17132
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Tropheryma whipplei (TW) is the root cause of Whipple's disease (WD), a rare infectious illness leading to multi-organ impairment. A prominent feature of WD is acute pneumonia, which can be exceedingly challenging to diagnose clinically due to the pathogen's surreptitious nature. However and significantly, with the advent of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF), it offers clinicians a potent tool at their disposal to detect TW infections. The present study conducted a retrospective analysis of clinical data gleaned from five patients in Hunan Province in China. Findings in this study demonstrated the potential of BALF-mNGS in diagnosing pneumonia caused by TW infection.
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页数：9
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